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Full-Text Articles in Medical Genetics
Multiple Metabolic Hits Converge On Cd36 As Novel Mediator Of Tubular Epithelial Apoptosis In Diabetic Nephropathy, Katalin Susztack, Emilio Ciccone, Peter Mccue, Kumar Sharma, Erwin Böttinger
Multiple Metabolic Hits Converge On Cd36 As Novel Mediator Of Tubular Epithelial Apoptosis In Diabetic Nephropathy, Katalin Susztack, Emilio Ciccone, Peter Mccue, Kumar Sharma, Erwin Böttinger
Department of Medicine Faculty Papers
Diabetic nephropathy (DNP) is a common complication of type 1 and type 2 diabetes mellitus and the most common cause of kidney failure. While DNP manifests with albuminuria and diabetic glomerulopathy, its progression correlates best with tubular epithelial degeneration (TED) and interstitial fibrosis. However, mechanisms leading to TED in DNP remain poorly understood.