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Articles 1 - 4 of 4
Full-Text Articles in Medical Cell Biology
Attenuated Negative Feedback In Monocyte-Derived Macrophages From Persons Living With Hiv: A Role For Ikaros, Celeste Faia, Karlie Plaisance-Bonstaff, Cecilia Vittori, Dorota Wyczechowska, Adam Lassak, Mary Meyaski-Schluter, Krzysztof Reiss, Francesca Peruzzi
Attenuated Negative Feedback In Monocyte-Derived Macrophages From Persons Living With Hiv: A Role For Ikaros, Celeste Faia, Karlie Plaisance-Bonstaff, Cecilia Vittori, Dorota Wyczechowska, Adam Lassak, Mary Meyaski-Schluter, Krzysztof Reiss, Francesca Peruzzi
School of Medicine Faculty Publications
Persons living with HIV (PLWH) are at higher risk of developing secondary illnesses than their uninfected counterparts, suggestive of a dysfunctional immune system in these individuals. Upon exposure to pathogens, monocytes undergo epigenetic remodeling that results in either a trained or a tolerant phenotype, characterized by hyper-responsiveness or hypo-responsiveness to secondary stimuli, respectively. We utilized CD14+ monocytes from virally suppressed PLWH and healthy controls for in vitro analysis following polarization of these cells toward a pro-inflammatory monocyte-derived macrophage (MDM) phenotype. We found that in PLWH-derived MDMs, pro-inflammatory signals (TNFA, IL6, IL1B, miR-155-5p, and IDO1) dominate over negative feedback signals (NCOR2, …
Interactions Of Mglur1/5 Transmission And Crf Signaling Following Adolescentalcohol Exposure & Adult Stress, John M. Lacey, Eleanor Holmgren, Tiffany Wills
Interactions Of Mglur1/5 Transmission And Crf Signaling Following Adolescentalcohol Exposure & Adult Stress, John M. Lacey, Eleanor Holmgren, Tiffany Wills
Medical Student Research Poster Symposium
Alcohol exposure in adolescence serves as a strong predictor of alcohol use disorder (AUD) in adulthood. Adolescence is time when alcohol drinking is commonly initiated and recent data points to sex differences in this consumption, with females consuming more alcohol during adolescence than males. Understanding the long-term consequences of adolescent alcohol exposure on neurocircuitry and behavior may help us identify the factors that increase AUD risk. Negative affect and stress are known to be common triggers for alcohol relapse and are also thought to be more powerful drivers for female drinking compared to male, whom are more likely to drink …
Sex Differences In The Effects Of Adolescent Alcohol Exposure, Rebecca K. Yoon, S.L. Rein, O.R. Brunke, Eleanor B. Holmgren, T. Henderson, C.R. Kasten, Tiffany Wills
Sex Differences In The Effects Of Adolescent Alcohol Exposure, Rebecca K. Yoon, S.L. Rein, O.R. Brunke, Eleanor B. Holmgren, T. Henderson, C.R. Kasten, Tiffany Wills
Medical Student Research Poster Symposium
Adolescent alcohol exposure is one of the strongest risk factors for the development of alcohol use disorder. Notably, affective disorders tend to emerge during this period of development as well. There is a growing body of evidence that suggests adolescent alcohol use in females is outpacing males, and that there are sex differences in various aspects of alcohol use. Women are more likely to use alcohol to blunt emotions of negative affective disorders such as anxiety and depression, while men are more likely to drink alcohol for the positive reward effects. To understand the underlying mechanism, it is necessary to …
Peroxisomal Multifunctional Protein 2 Deficiency Perturbs Lipid Homeostasis In The Retina And Causes Visual Dysfunction In Mice, Yannick Das, Daniëlle Swinkels, Sai Kocherlakota, Stefan Vinckier, Frédéric M. Vaz, Eric Wever, Antoine H.C. Van Kampen, Bokkyoo Jun, Khanh V. Do, Lieve Moons, Nicolas G. Bazan, Paul P. Van Veldhoven, Myriam Baes
Peroxisomal Multifunctional Protein 2 Deficiency Perturbs Lipid Homeostasis In The Retina And Causes Visual Dysfunction In Mice, Yannick Das, Daniëlle Swinkels, Sai Kocherlakota, Stefan Vinckier, Frédéric M. Vaz, Eric Wever, Antoine H.C. Van Kampen, Bokkyoo Jun, Khanh V. Do, Lieve Moons, Nicolas G. Bazan, Paul P. Van Veldhoven, Myriam Baes
School of Medicine Faculty Publications
Patients lacking multifunctional protein 2 (MFP2), the central enzyme of the peroxisomal β-oxidation pathway, develop retinopathy. This pathway is involved in the metabolism of very long chain (VLCFAs) and polyunsaturated (PUFAs) fatty acids, which are enriched in the photoreceptor outer segments (POS). The molecular mechanisms underlying the retinopathy remain, however, elusive. Here, we report that mice with MFP2 inactivation display decreased retinal function already at the age of 3 weeks, which is accompanied by a profound shortening of the photoreceptor outer and inner segments, but with preserved photoreceptor ultrastructure. Furthermore, MFP2 deficient retinas exhibit severe changes in gene expression with …