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Full-Text Articles in Medical Cell Biology
Profiling Igg N-Glycans As Potential Biomarker Of Chronological And Biological Ages: A Community-Based Study In A Han Chinese Population, Xinwei Yu, Youix Wang, Jasminka Krištić, Jing Dong, Xi Chu, Siqi Ge, Hao Wang, Honghong Fang, Qing Gao, Di Lui, Zhongya Zhao, Hongli Peng, Maja P. Baković, Lijuan Wu, Manshu Song, Igor Rudan, Harry Campbell, Gordan Lauc, Wei Wang
Profiling Igg N-Glycans As Potential Biomarker Of Chronological And Biological Ages: A Community-Based Study In A Han Chinese Population, Xinwei Yu, Youix Wang, Jasminka Krištić, Jing Dong, Xi Chu, Siqi Ge, Hao Wang, Honghong Fang, Qing Gao, Di Lui, Zhongya Zhao, Hongli Peng, Maja P. Baković, Lijuan Wu, Manshu Song, Igor Rudan, Harry Campbell, Gordan Lauc, Wei Wang
Research outputs 2014 to 2021
As an important post-translation modifying process, glycosylation significantly affects the structure and function of immunoglobulin G (IgG) molecules and is essential in many steps of the inflammatory cascade. Studies have demonstrated the potential of using glycosylation features of IgG as a component of predictive biomarkers for chronological age in several European populations, whereas no study has been reported in Chinese. Herein, we report various patterns of changes in IgG glycosylation associated with age by analyzing IgG glycosylation in 701 community-based Han Chinese (244 males, 457 females; 23-68 years old). Eleven IgG glycans, including FA2B, A2G1, FA2[6]G1, FA2[3]G1, FA2[6]BG1, FA2[3]BG1, A2G2, …