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Full-Text Articles in Medical Biotechnology
Depth And Size Limits For The Visibility Of Veins Using The Veinviewer Imaging System, Soujanya Ganesh
Depth And Size Limits For The Visibility Of Veins Using The Veinviewer Imaging System, Soujanya Ganesh
Theses and Dissertations (ETD)
Administration of fluids or medication and blood draw procedures require the nurse or the phlebotomist to access the veins in patients at hospitals or phlebotomy centers. It is important to minimize the discomfort associated with sticking needles in the patient more than once and most often, necessary to find an appropriate vein within few minutes. However, problems involved in accessing veins in pediatric and obese patients make it very difficult to perform a successful stick in a short time. The VeinViewer Imaging System is an infrared imaging device that provides the nurses and phlebotomists a means for locating veins in …
Adenoviral Mediated Gene Transfer Into The Dog Brain In Vivo, Marianela Candolfi, Kurt Kroeger, Elizabeth Pluhar, Chunyan Liu, Carlos Barcia, Josee Bergeron, Mariana Puntel, James Curtin, Elizabeth Mcniel, Andrew Freese, John Ohlfest, Peter Moore, William Kuoy, Pedro Lowenstein, Maria Castro
Adenoviral Mediated Gene Transfer Into The Dog Brain In Vivo, Marianela Candolfi, Kurt Kroeger, Elizabeth Pluhar, Chunyan Liu, Carlos Barcia, Josee Bergeron, Mariana Puntel, James Curtin, Elizabeth Mcniel, Andrew Freese, John Ohlfest, Peter Moore, William Kuoy, Pedro Lowenstein, Maria Castro
Articles
OBJECTIVE: Glioblastoma multiforme (GBM) is a devastating brain tumor for which there is no cure. Adenoviral-mediated transfer of conditional cytotoxic (herpes simplex virus [HSV] 1-derived thymidine kinase [TK]) and immunostimulatory (Fms-like tyrosine kinase 3 ligand [Flt3L]) transgenes elicited immune-mediated long-term survival in a syngeneic intracranial GBM model in rodents. However, the lack of a large GBM animal model makes it difficult to predict the outcome of therapies in humans. Dogs develop spontaneous GBM that closely resemble the human disease; therefore, they constitute an excellent large animal model. We assayed the transduction efficiency of adenoviral vectors (Ads) encoding beta-galactosidase (betaGal), TK, …