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Full-Text Articles in Medical Biochemistry
B-Cell Activating Factor As An Immunological Marker Of Disease Outcome And Treatment Response In Patients With Chronic Hepatitis B Virus Infection, Apichaya Khlaiphuengsin
B-Cell Activating Factor As An Immunological Marker Of Disease Outcome And Treatment Response In Patients With Chronic Hepatitis B Virus Infection, Apichaya Khlaiphuengsin
Chulalongkorn University Theses and Dissertations (Chula ETD)
B-cell activating factor (BAFF), an important cytokine for B lymphocyte activation that implicated in the pathogenesis and disease progression chronic hepatitis B (CHB) patients. This study aimed at evaluating clinical correlation and prognostic role of plasma BAFF, BAFF receptor and related polymorphisms in patients with CHB undergoing pegylated interferon (peg-IFN) treatment and HBV-related hepatocellular carcinoma (HCC). This study shown that BAFF levels were elevated during treatment but decreased to pre-treatment levels after peg-IFN cessation in HBeAg-positive CHB patients. Patients with HCC had significantly higher BAFF levels compared with the non-HCC group and healthy controls. Moreover, the frequency of rs9514828 CT+TT …
Systems Biology Of Human Cells Responded To Influenza B Virus Infection, Kritsada Sirivassanametha
Systems Biology Of Human Cells Responded To Influenza B Virus Infection, Kritsada Sirivassanametha
Chulalongkorn University Theses and Dissertations (Chula ETD)
Influenza B virus is a member of Orthomyxoviridae family which can cause influenza in human and affect to worldwide health problem. Systems biology is the computational modeling of molecular systems which is useful to predict how these biological systems change over time and under different conditions. In this study the multiomics was used to study human cellular response to influenza B virus infection. The transcriptome including mRNAs, lncRNAs and miRNAs and proteome were investigated by high-throughput technologies such as next-generation sequencing and mass spectrometry. The results showed that in human cells infected with influenza B virus, transcriptome including mRNAs, lncRNAs …