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Full-Text Articles in Medical Biochemistry
Proteasome Regulation Of Caspase-8: Significance In Cancer, Michael Vincent Fiandalo
Proteasome Regulation Of Caspase-8: Significance In Cancer, Michael Vincent Fiandalo
Theses and Dissertations--Molecular and Cellular Biochemistry
Anti-tumor therapeutic strategies based on combinations of chemotherapeutic agents with a death inducing ligand such as TNF-α Related Apoptosis Inducing Ligand (TRAIL), are directed towards selective and effective cancer cell apoptosis and enhanced therapeutic response. We previously demonstrated that proteasome inhibition sensitizes TRAIL resistant prostate cancer cells to TRAIL-mediated apoptosis via stabilization of the active p18 subunit of initiator caspase-8. The present study investigated the functional link between caspase-8 and the proteasome, by analyzing the impact of caspase-8 ubiquitination and proteasomal degradation on the outcomes of the extrinsic apoptosis pathway in cancer cells. Caspase-8 ubiquitination status was assessed by polyubiquitin …