Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Actin Cytoskeleton (1)
- Animals (1)
- Calcium (1)
- Calcium Signaling (1)
- Cardiac (1)
-
- Cell Line (1)
- Cytoplasmic Streaming (1)
- Enzyme Activation (1)
- Feedback (1)
- Feedback, Physiological (1)
- Homeostasis (1)
- Humans (1)
- Intracellular Membranes (1)
- MAP Kinase Signaling System (1)
- Membrane Potentials (1)
- Microtubules (1)
- Mitochondria (1)
- Mitogen-Activated Protein Kinases (1)
- Models (1)
- Models, Theoretical (1)
- Myoblasts (1)
- Myoblasts, Cardiac (1)
- Phosphorylation (1)
- Physiological (1)
- Ryanodine Receptor Calcium Release Channel (1)
- Theoretical (1)
Articles 1 - 2 of 2
Full-Text Articles in Medical Anatomy
Control Of Mitochondrial Motility And Distribution By The Calcium Signal: A Homeostatic Circuit., Muqing Yi, David Weaver, György Hajnóczky
Control Of Mitochondrial Motility And Distribution By The Calcium Signal: A Homeostatic Circuit., Muqing Yi, David Weaver, György Hajnóczky
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
Mitochondria are dynamic organelles in cells. The control of mitochondrial motility by signaling mechanisms and the significance of rapid changes in motility remains elusive. In cardiac myoblasts, mitochondria were observed close to the microtubular array and displayed both short- and long-range movements along microtubules. By clamping cytoplasmic [Ca2+] ([Ca2+]c) at various levels, mitochondrial motility was found to be regulated by Ca2+ in the physiological range. Maximal movement was obtained at resting [Ca2+]c with complete arrest at 1-2 microM. Movement was fully recovered by returning to resting [Ca2+]c, and inhibition could be repeated with no apparent desensitization. The inositol 1,4,5-trisphosphate- or …
Signaling Switches And Bistability Arising From Multisite Phosphorylation In Protein Kinase Cascades., Nick I Markevich, Jan B. Hoek, Boris N. Kholodenko
Signaling Switches And Bistability Arising From Multisite Phosphorylation In Protein Kinase Cascades., Nick I Markevich, Jan B. Hoek, Boris N. Kholodenko
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
Mitogen-activated protein kinase (MAPK) cascades can operate as bistable switches residing in either of two different stable states. MAPK cascades are often embedded in positive feedback loops, which are considered to be a prerequisite for bistable behavior. Here we demonstrate that in the absence of any imposed feedback regulation, bistability and hysteresis can arise solely from a distributive kinetic mechanism of the two-site MAPK phosphorylation and dephosphorylation. Importantly, the reported kinetic properties of the kinase (MEK) and phosphatase (MKP3) of extracellular signal-regulated kinase (ERK) fulfill the essential requirements for generating a bistable switch at a single MAPK cascade level. Likewise, …