Open Access. Powered by Scholars. Published by Universities.®
Animal experiment; animal model; animal tissue; article; binding affinity; binding site; cancer cell culture; cancer inhibition; cell proliferation; colon cancer; colon carcinogenesis; controlled study; down regulation; female; gene expression regulation; gene function; gene identification; gene location; gene targeting; human; human cell; human tissue; immunohistochemistry; in vitro study; molecular dynamics; mouse; nonhuman; Northern blotting; ovary cancer; priority journal; protein determination; protein expression; protein function; protein localization; protein targeting; quantitative analysis; real time polymerase chain reaction; reverse transcription polymerase chain reaction; tumor vascularization; Western blotting
Articles 1 - 1 of 1
Full-Text Articles in Medical Anatomy
Mir-145 Directly Targets P70s6k1 In Cancer Cells To Inhibit Tumor Growth And Angiogenesis., Qing Xu, Ling-Zhi Liu, Xu Qian, Qi Chen, Yue Jiang, Dan Li, Lihui Lai, Bing-Hua Jiang
Mir-145 Directly Targets P70s6k1 In Cancer Cells To Inhibit Tumor Growth And Angiogenesis., Qing Xu, Ling-Zhi Liu, Xu Qian, Qi Chen, Yue Jiang, Dan Li, Lihui Lai, Bing-Hua Jiang
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
MiR-145 can regulate cell apoptosis, proliferation, neural development and stem cell differentiation. Previous studies indicate that miR-145 is downregulated in human colon cancer cells. However, the molecular mechanisms of miR-145 used to regulate colon carcinogenesis and angiogenesis remain to be clarified. Here, we show that the expression of miR-145 is downregulated in colon and ovarian cancer tissues and cell lines. MiR-145 inhibits p70S6K1 post-transcriptional expression by binding to its 3'-UTR. The angiogenic factors hypoxia-inducible factor 1 (HIF-1) and vascular endothelial growth factor (VEGF), which are downstream molecules of p70S6K1, are decreased by miR-145 overexpression. P70S6K1 rescues miR-145-suppressed HIF-1 and VEGF …