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Full-Text Articles in Medical Anatomy
Il-15 Mediates Mitochondrial Activity Through A Pparšæ-Dependent-Pparš¼-Independent Mechanism In Skeletal Muscle Cells, ShantaĆ© M. Thornton, James E. Krolopp, Marcia J. Abbott
Il-15 Mediates Mitochondrial Activity Through A Pparšæ-Dependent-Pparš¼-Independent Mechanism In Skeletal Muscle Cells, ShantaĆ© M. Thornton, James E. Krolopp, Marcia J. Abbott
Health Sciences and Kinesiology Faculty Articles
Molecular mediators of metabolic processes, to increase energy expenditure, have become a focus for therapies of obesity. The discovery of cytokines secreted from the skeletal muscle (SKM), termed āmyokines,ā has garnered attention due to their positive effects on metabolic processes. Interleukin-15 (IL-15) is a myokine that has numerous positive metabolic effects and is linked to the PPAR family of mitochondrial regulators. Here, we aimed to determine the importance of PPARš¼ and/or PPARšæ as targets of IL-15 signaling. C2C12 SKM cells were differentiated for 6 days and treated every other day with IL-15 (100 ng/mL), a PPARš¼ inhibitor (GW-6471), a PPARšæ ā¦