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Full-Text Articles in Medical Anatomy
Serotonergic Innervation And Serotonin Receptor Expression Of Npy-Producing Neurons In The Rat Lateral And Basolateral Amygdaloid Nuclei., M Bonn, A Schmitt, K-P Lesch, E J Van Bockstaele, E Asan
Serotonergic Innervation And Serotonin Receptor Expression Of Npy-Producing Neurons In The Rat Lateral And Basolateral Amygdaloid Nuclei., M Bonn, A Schmitt, K-P Lesch, E J Van Bockstaele, E Asan
Department of Neuroscience Faculty Papers
Pharmacobehavioral studies in experimental animals, and imaging studies in humans, indicate that serotonergic transmission in the amygdala plays a key role in emotional processing, especially for anxiety-related stimuli. The lateral and basolateral amygdaloid nuclei receive a dense serotonergic innervation in all species studied to date. We investigated interrelations between serotonergic afferents and neuropeptide Y (NPY)-producing neurons, which are a subpopulation of inhibitory interneurons in the rat lateral and basolateral nuclei with particularly strong anxiolytic properties. Dual light microscopic immunolabeling showed numerous appositions of serotonergic afferents on NPY-immunoreactive somata. Using electron microscopy, direct membrane appositions and synaptic contacts between serotonin-containing axon …