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Genetic Structures Commons™

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Selected Works

2014

Articles 1 - 2 of 2

Full-Text Articles in Genetic Structures

Truncation Of Type Iv Pilin Induces Mucoidy In Pseudomonas Aeruginosa Strain Pao579, T. Ryan Withers, F. Heath Damron, Yeshi Yin, Hongwei D. Yu Jun 2014

Truncation Of Type Iv Pilin Induces Mucoidy In Pseudomonas Aeruginosa Strain Pao579, T. Ryan Withers, F. Heath Damron, Yeshi Yin, Hongwei D. Yu

Hongwei Yu

Pseudomonas aeruginosa is a Gram negative, opportunistic pathogen that uses the overproduction of alginate, a surface polysaccharide, to form biofilms in vivo. Overproduction of alginate, also known as mucoidy, affords the bacterium protection from the host's defenses and facilitates the establishment of chronic lung infections in individuals with cystic fibrosis. Expression of the alginate biosynthetic operon is primarily controlled by the alternative sigma factor AlgU (AlgT/σ22). In a nonmucoid strain, AlgU is sequestered by the transmembrane antisigma factor MucA to the cytoplasmic membrane. AlgU can be released from MucA via regulated intramembrane proteolysis by proteases AlgW and MucP causing the …

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Estudo De Associação Entre Os Polimorfismos De Um Único Nucleotídeo Em Genes De Citocinas E A Doença Renal Policística Autossômica Dominante Em Uma População Brasileira, Everton Fernando Alves Mar 2014

Estudo De Associação Entre Os Polimorfismos De Um Único Nucleotídeo Em Genes De Citocinas E A Doença Renal Policística Autossômica Dominante Em Uma População Brasileira, Everton Fernando Alves

Everton Fernando Alves

A doença Renal Policística Autossômica Dominante (DRPAD) é causada por mutações em um de dois genes, PKD1 ou PKD2, que resultam em acúmulos de cistos nos rins. O objetivo deste trabalho foi verificar a existência de possíveis associações entre variantes em genes de citocinas e em receptores de citocinas para as posições IL1A-889 (rs1800587), IL1B-511, +3962 (rs16944, rs1143634), IL1R1970 (rs2234650), IL1RA11100 (rs315952), IL4RA+1902 (rs1801275), IL12-1188 (rs3212227), IFNG+874 (rs2430561), TGFB1códon 10, códon 25 (rs1982073, rs1800471), TNF-308, -238 (rs1800629, rs361525), IL2-330, +166 (rs2069762, rs2069763), IL4-1098, -590, -33 (rs2243248, rs2243250, rs2070874), IL6-174, nt565 (rs1800795, rs1800797) e IL10-1082,-819,-592 (rs1800896, rs1800871, rs1800872) e a DRPAD. …

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