Genetic Phenomena Commons^™

Triple Negative Breast Cancer In An Appalachian Region: Exponential Tumor Grade Increase With Age Of Diagnosis, Gina Sizemore, Toni Marie Rudisill

Journal of Appalachian Health

Introduction: Triple negative breast cancer is an aggressive breast cancer with decreased five-year survival, increased risk for recurrence, and higher risk for metastases. Unlike other breast cancers, it has no targeted treatment and has heterogeneous genetics which make classification and treatment difficult.

Purpose: The purpose of our research was to compare triple negative breast cancer to non-triple negative breast cancer to identify key epidemiologic factors that might lead to improved basic science directives for biomarkers, treatments, and classification.

Methods: The state cancer registry was used to provide the first West Virginia state-wide population evaluation of triple negative breast cancer.

Results: …

Examining Perceptions Of Anorexia Nervosa, Polly Mcgonigle

Undergraduate Honors Theses

Anorexia nervosa (AN) is an eating disorder characterized by a restriction of energy intake, an intense fear of gaining weight, and often distorted body image. AN has the second highest mortality rate of all psychiatric disorders, due to high suicide rates and medical complications associated with malnutrition. An estimated 10% of those who have AN die because of the disorder (Insel, 2012). Interacting factors—genetic, biological, environmental, and psychosocial—contribute to the etiology and maintenance of AN. However, outside of research settings, AN is misunderstood as having primarily environmental roots (Salafia, et. al). Blame is placed on societal expectations and the disorder …

Neuroscience And The Future Of Personhood And Responsibility, Stephen J. Morse

All Faculty Scholarship

This is a chapter in a book, Constitution 3.0: Freedom and Technological Change, edited by Jeffrey Rosen and Benjamin Wittes and published by Brookings. It considers whether likely advances in neuroscience will fundamentally alter our conceptions of human agency, of what it means to be a person, and of responsibility for action. I argue that neuroscience poses no such radical threat now and in the immediate future and it is unlikely ever to pose such a threat unless it or other sciences decisively resolve the mind-body problem. I suggest that until that happens, neuroscience might contribute to the reform of …