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Articles 1 - 8 of 8
Full-Text Articles in Medical Sciences
Developing A Culturally Competent Health Network: A Planning Framework And Guide, Eric Gertner, Judith Sabino, Erica Mahady, Lynn Deitrick, Jarret Patton, Mary Grim, James Geiger, Debbie Salas-Lopez
Developing A Culturally Competent Health Network: A Planning Framework And Guide, Eric Gertner, Judith Sabino, Erica Mahady, Lynn Deitrick, Jarret Patton, Mary Grim, James Geiger, Debbie Salas-Lopez
Debbie Salas-Lopez MD, MPH
No abstract provided.
Baseline Intercultural Sensitivity Assessment Among Employees At A Large Health Network: Findings And Implications For Cultural Competency Interventions, Eric Gertner, Jarret Patton, Jay Baglia, Judith Sabino, Lynn Deitrick, Anthony Nerino, Debbie Salas-Lopez
Baseline Intercultural Sensitivity Assessment Among Employees At A Large Health Network: Findings And Implications For Cultural Competency Interventions, Eric Gertner, Jarret Patton, Jay Baglia, Judith Sabino, Lynn Deitrick, Anthony Nerino, Debbie Salas-Lopez
Debbie Salas-Lopez MD, MPH
No abstract provided.
An Ecological Approach To Organizational Transformation: The Growth Of Cross-Cultural Health Care Delivery In An Academic Community Health Network, James Geiger, Judith Sabino, Eric Gertner, Jarret Patton, Llewellyn Cornelius, Debbie Salas-Lopez
An Ecological Approach To Organizational Transformation: The Growth Of Cross-Cultural Health Care Delivery In An Academic Community Health Network, James Geiger, Judith Sabino, Eric Gertner, Jarret Patton, Llewellyn Cornelius, Debbie Salas-Lopez
Debbie Salas-Lopez MD, MPH
No abstract provided.
An Ecological Approach To Organizational Cultural Competence, Judith Sabino, Jarret Patton, Erica Mahady, Lynn Deitrick, James Geiger, Marykay Grim, Debbie Salas-Lopez
An Ecological Approach To Organizational Cultural Competence, Judith Sabino, Jarret Patton, Erica Mahady, Lynn Deitrick, James Geiger, Marykay Grim, Debbie Salas-Lopez
Debbie Salas-Lopez MD, MPH
No abstract provided.
Transcriptome Profiling Of Spinal Muscular Atrophy Motor Neurons Derived From Mouse Embryonic Stem Cells., Miho Maeda, Ashlee W Harris, Brewster F Kingham, Casey J Lumpkin, Lynn M Opdenaker, Suzanne M Mccahan, Wenlan Wang, Matthew E R Butchbach
Transcriptome Profiling Of Spinal Muscular Atrophy Motor Neurons Derived From Mouse Embryonic Stem Cells., Miho Maeda, Ashlee W Harris, Brewster F Kingham, Casey J Lumpkin, Lynn M Opdenaker, Suzanne M Mccahan, Wenlan Wang, Matthew E R Butchbach
Department of Pediatrics Faculty Papers
Proximal spinal muscular atrophy (SMA) is an early onset, autosomal recessive motor neuron disease caused by loss of or mutation in SMN1 (survival motor neuron 1). Despite understanding the genetic basis underlying this disease, it is still not known why motor neurons (MNs) are selectively affected by the loss of the ubiquitously expressed SMN protein. Using a mouse embryonic stem cell (mESC) model for severe SMA, the RNA transcript profiles (transcriptomes) between control and severe SMA (SMN2+/+;mSmn-/-) mESC-derived MNs were compared in this study using massively parallel RNA sequencing (RNA-Seq). The MN differentiation efficiencies between control and severe SMA mESCs …
Proteomic Assessment Of A Cell Model Of Spinal Muscular Atrophy., Chia-Yen Wu, Dosh Whye, Lisa Glazewski, Leila Choe, Douglas Kerr, Kelvin H Lee, Robert W Mason, Wenlan Wang
Proteomic Assessment Of A Cell Model Of Spinal Muscular Atrophy., Chia-Yen Wu, Dosh Whye, Lisa Glazewski, Leila Choe, Douglas Kerr, Kelvin H Lee, Robert W Mason, Wenlan Wang
Department of Pediatrics Faculty Papers
BACKGROUND: Deletion or mutation(s) of the survival motor neuron 1 (SMN1) gene causes spinal muscular atrophy (SMA), a neuromuscular disease characterized by spinal motor neuron death and muscle paralysis. Complete loss of the SMN protein is embryonically lethal, yet reduced levels of this protein result in selective death of motor neurons. Why motor neurons are specifically targeted by SMN deficiency remains to be determined. In this study, embryonic stem (ES) cells derived from a severe SMA mouse model were differentiated into motor neurons in vitro by addition of retinoic acid and sonic hedgehog agonist. Proteomic and western blot analyses were …
Autistic Disorder Associated With A Paternally Derived Unbalanced Translocation Leading To Duplication Of Chromosome 15pter-Q13.2: A Case Report., David J Wu, Nicholas J Wang, Jennette Driscoll, Naghmeh Dorrani, Dahai Liu, Marian Sigman, N Carolyn Schanen
Autistic Disorder Associated With A Paternally Derived Unbalanced Translocation Leading To Duplication Of Chromosome 15pter-Q13.2: A Case Report., David J Wu, Nicholas J Wang, Jennette Driscoll, Naghmeh Dorrani, Dahai Liu, Marian Sigman, N Carolyn Schanen
Department of Pediatrics Faculty Papers
Autism spectrum disorders have been associated with maternally derived duplications that involve the imprinted region on the proximal long arm of chromosome 15. Here we describe a boy with a chromosome 15 duplication arising from a 3:1 segregation error of a paternally derived translocation between chromosome 15q13.2 and chromosome 9q34.12, which led to trisomy of chromosome 15pter-q13.2 and 9q34.12-qter. Using array comparative genome hybridization, we localized the breakpoints on both chromosomes and sequence homology suggests that the translocation arose from non-allelic homologous recombination involving the low copy repeats on chromosome 15. The child manifests many characteristics of the maternally-derived duplication …
Multiple Forms Of Atypical Rearrangements Generating Supernumerary Derivative Chromosome 15., Nicholas J Wang, Alexander S Parokonny, Karen N Thatcher, Jennette Driscoll, Barbara M Malone, Naghmeh Dorrani, Marian Sigman, Janine M Lasalle, N Carolyn Schanen
Multiple Forms Of Atypical Rearrangements Generating Supernumerary Derivative Chromosome 15., Nicholas J Wang, Alexander S Parokonny, Karen N Thatcher, Jennette Driscoll, Barbara M Malone, Naghmeh Dorrani, Marian Sigman, Janine M Lasalle, N Carolyn Schanen
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
BACKGROUND: Maternally-derived duplications that include the imprinted region on the proximal long arm of chromosome 15 underlie a complex neurobehavioral disorder characterized by cognitive impairment, seizures and a substantial risk for autism spectrum disorders1. The duplications most often take the form of a supernumerary pseudodicentric derivative chromosome 15 [der(15)] that has been called inverted duplication 15 or isodicentric 15 [idic(15)], although interstitial rearrangements also occur. Similar to the deletions found in most cases of Angelman and Prader Willi syndrome, the duplications appear to be mediated by unequal homologous recombination involving low copy repeats (LCR) that are found clustered in the …