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Full-Text Articles in Medical Sciences
Effects Of A Leucine Supplementation On Mitochondrial Markers In Pre-Cachectic Female Mice, Breanna Williams
Effects Of A Leucine Supplementation On Mitochondrial Markers In Pre-Cachectic Female Mice, Breanna Williams
Biological Sciences Undergraduate Honors Theses
Cancer cachexia is a wasting syndrome characterized by extreme weight and skeletal muscle loss that results in death in many tumor bearing individuals. Because skeletal muscle requires a high amount of energy to function, skeletal muscle fiber cells need healthy mitochondria to function. When skeletal muscle loss atrophy occurs, the mitochondrial network is degraded. Different treatments for this muscle atrophy are being studied, one of which is a leucine supplementation since leucine has been found to stimulate skeletal muscle growth in other studies. However, current data suggests that a leucine supplementation in cachexic individuals exacerbates this atrophy. PURPOSE: This study …
Mechanisms And Therapeutic Interventions For Breast Cancer-Induced Fatigue And Mitochondrial Dysfunction, David Andrew Stanton
Mechanisms And Therapeutic Interventions For Breast Cancer-Induced Fatigue And Mitochondrial Dysfunction, David Andrew Stanton
Graduate Theses, Dissertations, and Problem Reports
According to the latest statistics from the National Cancer Institute (NCI), about 1 in 8 U.S. women (~13%) will develop invasive breast cancer over the course of their lifetime. This translates to an estimated 268,600 new cases of breast cancer for the year 2019, and these diagnoses will collectively make up 15% of all new cancer cases across all cancer types. The majority of these women will experience the often-debilitating symptom of breast cancer-induced fatigue. these patients often have difficulty performing normal activities of daily living, have decreased tolerance to traditional tumor-directed therapies, and have higher rates of cancer recurrence. …
Comparative Plasma Proteomics In Muscle Atrophy Induced By Cancer Cachexia And Hindlimb Unloading, Kirsten Rene Dunlap
Comparative Plasma Proteomics In Muscle Atrophy Induced By Cancer Cachexia And Hindlimb Unloading, Kirsten Rene Dunlap
Graduate Theses and Dissertations
Introduction: Muscle atrophy results from a dysfunction in protein turnover that leads to loss of mass and function and occurs concurrently with multiple pathologies such as cancer and extended bed rest. Atrophy reduces overall quality of life while increasing morbidity and mortality. Currently, efficacious therapeutic interventions to treat and prevent muscle wasting in all its forms are lacking, however if conserved mechanisms can be identified between wasting conditions, this would aid in the development of multipurpose therapeutics to ameliorate this pathology. Purpose: To examine circulating factors present across atrophic pathologies. Methods: 35 male C57BL/6J mice were assigned to hindlimb unloading …