Skin and Connective Tissue Diseases Commons^™

Does Enhancing Epidermal Barrier Function With Moisturizing Topical Products Improve Acne Vulgaris In Adult Patients Compared To Non-Moisturizing Products Or Non-Intervention?, Aziza Jadallah

Capstone Showcase

Introduction: Acne is a common skin disorder with multifactorial causes that can persist beyond adolescence or appear for the first time in adulthood. Treatments of varying potency exist, ranging from over-the-counter face washes and creams to prescription topical and oral treatments. Current treatment guidelines target sebum production, exfoliation of excess skin cells, and the bacteria Propionibacterium acnes. Research as early as 1995 suggests dysfunctions of the skin barrier, such as abnormal ceramide levels and increased water loss, play a role in the pathophysiology of acne and are not addressed by current treatments. This review analyzes the role of moisturizing …

Elevated Homeostatic Model Assessment Of Insulin Resistance Level Increases The Risk Of Acne, Stefani Nurhadi, Igaa Praharsini, Aagp Wiraguna

Journal of General - Procedural Dermatology & Venereology Indonesia

Background: Insulin resistance and high carbohydrate diets are currently considered to be influential in acne aetiology. Insulin is a hormone that does not only regulate the concentration of blood glucose but also affects the production of sebum and through the Insulin Growth Factor-1 (IGF-1) receptor stimulates androgen synthesis which will increase the proliferation of keratinocytes duct and the production of sebum in acne of the pilosebaceous.

Methods: This is a cross sectional observational analytic study involving 38 acne patients and 38 controls. This study aims to determine whether the increase in Homeostatic Model Assessment of Insulin Resistance …

Comparative Study Of Two Diagnostic Methods Of Demodicosis In Patients With Acne And Rosacea, Anzhela Kravchenko

Journal of General - Procedural Dermatology & Venereology Indonesia

Background: Demodicosis is a disease, caused by parasitisation of the opportunistic parasites from the acariasis group – Demodex mites. This article presents a comparative study of two methods (light microscopy of skin scrapings and confocal laser scanning in vivo microscopy) for identification of Demodex mites on the facial skin in acne and rosacea patients. The use of confocal laser scanning in vivo microscopy in dermatology today is considered as one of the most promising methods.

Methods: A total of 90 subjects were included in the study, comprising 30 patients with acne and rosacea complicated by demodicosis, 30 patients …

Is A Once Daily Topical Application Of Fixed-Dose Combination Gel Containing Adapalene 0.1%-Benzoyl Peroxide (Bpo) 2.5%(Adapalene-Bpo) Effective At Treating Mild To Moderate Acne?, Kelly A. Weitzel

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not a once daily topical application of fixed-dose combination gel containing adapalene 0.1%-benzoyl peroxide (BPO) 2.5% (adapalene-BPO) is effective at treating mild to moderate acne.

STUDY DESIGN: Three multi-center double blind randomized control studies published in the English language between 2007-2013.

STUDY SOURCES: Three peer-reviewed RCTS were found using Pubmed. These studies compared the same fixed-dose combination gel adapalene-BPO against placebo vehicles. Two studies also compared to additional groups receiving monotherapies.

OUTCOMES MEASURED: Outcomes measured were improvement of participant’s acne according to the Investigator’s Global Assessment of …

Is Glycolic Acid Safe And Effective In The Treatment Of Mild To Moderate Acne?, Brittany Stokes

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EMB review is to determine whether or not the use of glycolic acid is effective in the treatment of inflammatory and non-inflammatory acne.

STUDY DESIGN: The review of three randomized, double-blind, controlled trials all published in English language between the years of 2008-2010.

DATA SOURCES: Three randomized, double-blind, controlled trails comparing glycolic acid to a visually matched placebo or pharmaceutical therapy in improvement of acne. All articles were found using PubMed and EBSCO.

OUTCOMES MEASURED: The improvement of inflammatory and non-inflammatory acne and tolerance/ safety of the intervention. Efficacy was …

Is A Low Glycemic Index Diet An Effective Treatment Regimen For Acne Vulgaris In Adolescents And Young Adults Ages 15-30?, Gina C. Tomkus

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not a low glycemic index (Low GI) diet is an effective treatment for acne vulgaris in adolescents and young adults ages 15-30.

STUDY DESIGN: Systematic review of two randomized, double blind, placebo controlled clinical trial and one parallel clinical trial published in peer-reviewed journals.

DATA SOURCES: Two randomized double blind clinical trials and one parallel clinical trial published in 2007, 2012, and 2010 respectively. The sources studying the use of a low glycemic index diet as a therapeutic intervention for acne vulgaris were obtained …

Is Dapsone Gel Safe And Effective For The Treatment Of Acne Vulgaris?, Amy Patel

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not dapsone gel is safe and effective for the treatment of acne vulgaris.

STUDY DESIGN: A review of three English language studies published in 2007. Includes two randomized, double-blind, controlled trials and one open label, noncomparative study. DATA SOURCES: Randomized, controlled trials comparing dapsone gel to vehicle gel control were found using PubMed and Cochrane database.

OUTCOMES MEASURED: Success on the Global Acne Assessment Score (GAAS) and reduction in acne lesion counts

RESULTS: The two randomized, controlled trials and the open-label noncomparative study …