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2009

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Full-Text Articles in Skin and Connective Tissue Diseases

Expression And Function Of Hypoxia Inducible Factor-1 Alpha In Human Melanoma Under Non-Hypoxic Conditions, Caroline N. Mills, Sandeep S. Joshi, Richard M. Niles Nov 2009

Expression And Function Of Hypoxia Inducible Factor-1 Alpha In Human Melanoma Under Non-Hypoxic Conditions, Caroline N. Mills, Sandeep S. Joshi, Richard M. Niles

Biochemistry and Microbiology

Background

Hypoxia inducible factor-1 alpha (HIF-1α) protein is rapidly degraded under normoxic conditions. When oxygen tensions fall HIF-1α protein stabilizes and transactivates genes involved in adaptation to hypoxic conditions. We have examined the normoxic expression of HIF-1α RNA and protein in normal human melanocytes and a series of human melanoma cell lines isolated from radial growth phase (RGP), vertical growth phase (VGP) and metastatic (MET) melanomas.

Results

HIF-1α mRNA and protein was increased in RGP vs melanocytes, VGP vs RGP and MET vs VGP melanoma cell lines. We also detected expression of a HIF-1α mRNA splice variant that lacks part …

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John Contracts Skin Disease At Spa, Donna M. Hughes Dr., Melanie Shapiro Esq Oct 2009

John Contracts Skin Disease At Spa, Donna M. Hughes Dr., Melanie Shapiro Esq

Donna M. Hughes

A virus that causes a skin disease called Molluscum contagiosum is being spread at a spa-brothel in Providence. Molluscum contagiosum is a skin disease caused by a virus. The infection causes small white, pink, or flesh-colored bumps or growths on areas which came in contact with the infected skin of another person. Molluscum contagiosum can be treated or will disappear on its own, although it takes time. According to the Center for Disease Control “the bumps disappear on their own within 6 months. However, they may not go away completely for up to 4 years.” The person can infect another …

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