Skin and Connective Tissue Diseases Commons^™

The Effect Of Fetal Age On Skin Permeability In Guinea Pigs, Benita Stiles Whitted

Loma Linda University Electronic Theses, Dissertations & Projects

Preliminary investigation has indicated large decreases in fetal skin permeability during the latter half of gestation (Parmley and Seeds, 1970; Treager, 1966). The purpose of this study was to demonstrate the degree of skin permeability in fetal guinea pigs at various gestational stages. The test hypothesis was that these skins would show a significant decrease in permeability to tritiated water when tested at time increments through out the latter half of gestation.

In vitro skin permeability to tritiated water was measured in samples from 22 guinea pig fetuses. Gestational age ranged from 30 to 65 days in increments of five, …