Skin and Connective Tissue Diseases Commons^™

Systematic Condition In A Ncaa-I Collegiate Soccer Player, Ashley D. Smith

Theses, Dissertations and Capstones

Objective: The purpose of this case study is to inform athletic trainers of a systematic disease not common in our patient population.

Background: The athlete, a twenty-one YO, 160 lb, 69 inch female NCAA-I collegiate soccer goalie presented with complaint of bilateral elbow and knee joint pain and stiffness along with tender red itchy bumps on the anterior aspect of her shins. The athlete had flu-like symptoms and a URI prior to this complaint. The athlete has a history of anemia, mononucleosis, and streptococcal.

Differential Diagnosis: Rheumatoid arthritis, lymphoma, HIV/aids, erythema nodosum, lupus, Lyme disease.

Treatment: The athlete sought out …

Expression And Function Of Hypoxia Inducible Factor-1 Alpha In Human Melanoma Under Non-Hypoxic Conditions, Caroline N. Mills, Sandeep S. Joshi, Richard M. Niles

Biochemistry and Microbiology

Background

Hypoxia inducible factor-1 alpha (HIF-1α) protein is rapidly degraded under normoxic conditions. When oxygen tensions fall HIF-1α protein stabilizes and transactivates genes involved in adaptation to hypoxic conditions. We have examined the normoxic expression of HIF-1α RNA and protein in normal human melanocytes and a series of human melanoma cell lines isolated from radial growth phase (RGP), vertical growth phase (VGP) and metastatic (MET) melanomas.

Results

HIF-1α mRNA and protein was increased in RGP vs melanocytes, VGP vs RGP and MET vs VGP melanoma cell lines. We also detected expression of a HIF-1α mRNA splice variant that lacks part …

Effects Of Retinoic Acid On Beta-Catenin Transcriptional Activity In Melanoma Cells, Fung Chan

Theses, Dissertations and Capstones

Melanoma is the most dangerous form of skin cancer and its incidence has been increasing in the United States. Most melanomas are resistant to current chemotherapies; therefore, understanding the mechanism of melanomagenesis is beneficial to treatment of the diseases. Accumulation of β-catenin has been shown in colon and other cancers, including melanomas, but the transcriptional role of β-catenin in melanomas is still unclear. All-trans retinoic acid (ATRA) is an anti-tumor agent that has an inhibitory effect on β-catenin, but this effect has not been studied in melanomas. It has been shown that Microphthalmia-associated transcription factor (MITF), a melanocyte specific protein, …