Open Access. Powered by Scholars. Published by Universities.®
Skin and Connective Tissue Diseases Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Animals (1)
- Arthritis, Rheumatoid (1)
- Cancer (1)
- Cell hypoxia/drug effects (1)
- Cell line (1)
-
- Disease Models, Animal (1)
- Epitopes (1)
- HIF-1a (1)
- Inflammation (1)
- Jefferson Medical College (1)
- MPNST (1)
- Malignant peripheral nerve sheath tumor (1)
- Melanocytes (1)
- Mice (1)
- Mice, Inbred C57BL (1)
- Neural tumors (1)
- Neurofibromatosis (1)
- Neurosurgery (1)
- Osteopontin (1)
- Presentation (1)
- RNA, Messenger (1)
- Ras (1)
- Rheumatoid arthritis (1)
- Sarcoma (1)
- Sialoglycoproteins (1)
- Skin cancer (1)
- Soft tissue sarcoma (1)
- Tim Beer (1)
- Timothy Beer (1)
- Tumor (1)
Articles 1 - 3 of 3
Full-Text Articles in Skin and Connective Tissue Diseases
Osteopontin: A Bridge Between Bone And The Immune System, Ellen M. Gravallese
Osteopontin: A Bridge Between Bone And The Immune System, Ellen M. Gravallese
Ellen M. Gravallese
The molecular mechanisms underlying the putative role of osteopontin in the chronic inflammatory disease rheumatoid arthritis are unclear. A study in a murine model of arthritis now demonstrates that a specific antibody directed against the exposed osteopontin epitope SLAYGLR is capable of preventing inflammatory cell infiltration in arthritic joints.
Expression And Function Of Hypoxia Inducible Factor-1 Alpha In Human Melanoma Under Non-Hypoxic Conditions, Caroline N. Mills, Sandeep S. Joshi, Richard M. Niles
Expression And Function Of Hypoxia Inducible Factor-1 Alpha In Human Melanoma Under Non-Hypoxic Conditions, Caroline N. Mills, Sandeep S. Joshi, Richard M. Niles
Richard M. Niles
Background Hypoxia inducible factor-1 alpha (HIF-1α) protein is rapidly degraded under normoxic conditions. When oxygen tensions fall HIF-1α protein stabilizes and transactivates genes involved in adaptation to hypoxic conditions. We have examined the normoxic expression of HIF-1α RNA and protein in normal human melanocytes and a series of human melanoma cell lines isolated from radial growth phase (RGP), vertical growth phase (VGP) and metastatic (MET) melanomas. Results HIF-1α mRNA and protein was increased in RGP vs melanocytes, VGP vs RGP and MET vs VGP melanoma cell lines. We also detected expression of a HIF-1α mRNA splice variant that lacks part …
Malignant Peripheral Nerve Sheath Tumor (Mpnst): An Overview With Emphasis On Pathology, Imaging And Management Strategies., Timothy C. Beer
Malignant Peripheral Nerve Sheath Tumor (Mpnst): An Overview With Emphasis On Pathology, Imaging And Management Strategies., Timothy C. Beer
Timothy C Beer
MPNSTs are rare malignancies that are classically associated with pre-existing plexiform neurofibromas in neurofibromatosis type 1 (NF-1) patients, but also occur in association with radiation as well as sporadically in patients with no known risk factors. The typical presentation of sporadic MPNST is a new painless enlarging mass. The typical presentation of MPNST in an NF-1 patient is rapid enlargement or new onset of pain associated with a pre-existing plexiform neurofibroma. Although both MPNST and benign neurofibromas share in common the absence of neurofibromin function due to loss of both NF-1 alleles, malignant transformation to MPNST requires several additional aberrations, …