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Characterizing The Cellular, Molecular, And Behavioural Pathology Of Repetitive Mtbi In A Human Tau Transgenic Mouse, Morgan A. Walker
Characterizing The Cellular, Molecular, And Behavioural Pathology Of Repetitive Mtbi In A Human Tau Transgenic Mouse, Morgan A. Walker
Electronic Thesis and Dissertation Repository
After an episode of repetitive mild traumatic brain injury (rmTBI), many cellular and molecular cascades are initiated that result in the disruption of the structural and chemical integrity of the components in the brain, leading to the development of various cognitive deficits. The goal of this thesis was to evaluate a mouse model of concussion in order to study the relationship between rmTBI, GSK3β and tau phosphorylation, and behavioural outcomes in a transgenic mouse line expressing solely human tau. We found that there was increased phosphorylation of the two main regulatory sites on GSK3β, Tyr216 and Ser9, in the C57BL/6 …
Trna Regulation In Humans: The Cellular Effect Of A Pathological Hars Y454s Mutation, Rosan Kenana
Trna Regulation In Humans: The Cellular Effect Of A Pathological Hars Y454s Mutation, Rosan Kenana
Electronic Thesis and Dissertation Repository
tRNAs are the adapter molecules involved in translating the genetic code into functional protein in a living cell. tRNAs are charged with their cognate amino acids - by aminoacyl-tRNA synthetases (aaRS or ARS) - which are then transferred to a growing peptide in a process called mRNA translation. The efficiency of translation is dependent on the ratio of ARS enzymes to their cognate tRNAs and the availability of correctly amino acylated tRNAs. Disruptions of this process, caused by mutations in ARS genes, in particular, have been linked to complex inherited diseases. USH3B syndrome, a recessively inherited disorder among consanguineous families …