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Is Lubiprostone Effective In Treating Symptoms Of Chronic Constipation?, Christine M. Macdonald
Is Lubiprostone Effective In Treating Symptoms Of Chronic Constipation?, Christine M. Macdonald
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this selective EBM review is to determine whether or not lubiprostone is effective in treating symptoms of chronic constipation.
STUDY DESIGN: Review of three English language primary randomized controlled trials from 2007- 2010.
DATA SOURCES: Three double-blind, randomized, controlled trials were found using PubMed. These studies compared treatment with lubiprostone to a visually matched placebo.
OUTCOME MEASURED: The frequency of each patient’s spontaneous bowel movements within the first 24 hours after initial treatment was recorded from the data collected from the patient’s daily diary.
RESULTS: All three trails demonstrated a statistically significant improvement in the rates …