Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Aging (1)
- Autophagy. (1)
- Biomarker (1)
- Calcium oxalate (1)
- Diagnosis (1)
-
- Digital Rectal Examination (1)
- Drosophila melanogaster (1)
- Ectosome (1)
- Exosome (1)
- Extracellular Vesicle (1)
- Liquid Biopsy (1)
- MTOR (1)
- Malpighian tubule (1)
- Metabolic syndrome (1)
- Microparticle (1)
- Nephrolithiasis (1)
- Prostate Cancer (1)
- Rapamycin (1)
- Reactive oxygen species (1)
- Risk Stratification (1)
- Sodium oxalate (1)
Articles 1 - 2 of 2
Full-Text Articles in Male Urogenital Diseases
The Effect Of Mtor Inhibitor Rapamycin On A Dietary Drosophila Melanogaster Model Of Calcium Oxalate Nephrolithiasis, Michael T. Pignanelli
The Effect Of Mtor Inhibitor Rapamycin On A Dietary Drosophila Melanogaster Model Of Calcium Oxalate Nephrolithiasis, Michael T. Pignanelli
Electronic Thesis and Dissertation Repository
Impaired cellular tolerance of reactive oxygen species (ROS) has been suggested as a common mechanistic link associated with aging in both metabolic syndrome and nephrolithiasis. The mechanistic (mammalian) target of rapamycin (mTOR) activity is characteristic of metabolic syndrome. When nutrients are abundant, mTOR is active. Conversely, fasting inhibits mTOR. Metabolic syndrome is correlated with an increased risk of self-reported or imaging findings of nephrolithiasis. At the individual level, patients with a higher BMI have an increased prevalence of recurrent symptomatic nephrolithiasis, 24-hour urinary excretion of oxalate, sodium, uric acid, calcium, and phosphorous as well as lower pH. Calcium oxalate crystals …
Prostate Cancer Microparticles In Men Undergoing Radical Prostatectomy, Malcolm James Dewar
Prostate Cancer Microparticles In Men Undergoing Radical Prostatectomy, Malcolm James Dewar
Electronic Thesis and Dissertation Repository
Objectives: To determine changes in prostate microparticle (PMP) concentrations in men with prostate cancer (PCa) after digital rectal examination (DRE), after radical prostatectomy (RP), and at follow-up.
Materials and Methods: 22 men were recruited before RP. Four blood specimens were collected – baseline (specimen 1), post-DRE (specimen 2), immediately post-RP (specimen 3), and follow-up (specimen 4). Pre- and post-DRE urine was collected (Specimen A and B respectively). Flow cytometric analysis of biofluids was performed with fluorescent-labeled antibodies against prostate-specific membrane antigen (PSMA) and polysialic acid. Total MP (TMP) and dual positive (PMP) events per µl of plasma or urine were …