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Full-Text Articles in Male Urogenital Diseases
Epigenetic Regulation Of Prostate Cancer, Ruixin Wang, Xiaoqi Liu
Epigenetic Regulation Of Prostate Cancer, Ruixin Wang, Xiaoqi Liu
Toxicology and Cancer Biology Faculty Publications
Prostate cancer is (PCa) the second leading cause of cancer death in males in the United State, with 174,650 new cases and 31,620 deaths estimated in 2019. It has been documented that epigenetic deregulation such as histone modification and DNA methylation contributes to PCa initiation and progression. EZH2 (enhancer of zeste homolog 2), the catalytic subunit of the Polycomb Repressive Complex (PRC2) responsible for H3K27me3 and gene repression, has been identified as a promising target in PCa. In addition, overexpression of other epigenetic regulators such as DNA methyltransferases (DNMT) is also observed in PCa. These epigenetic regulators undergo extensive post-translational …
Genitourinary Effects Of Smoking In Men: An Alternative Approach To Smoking Cessation Through Patient Education, Michael J. Lawrence
Genitourinary Effects Of Smoking In Men: An Alternative Approach To Smoking Cessation Through Patient Education, Michael J. Lawrence
Family Medicine Clerkship Student Projects
Smoking remains a prominent problem in Vermont, especially outside Chittenden County. The genitourinary effects of smoking tend to be poorly appreciated among patients. This presents an opportunity for further patient education and incentivization to quit. This project focused on the genitourinary effects of smoking in men, specifically highlighting how smoking increases risk of bladder cancer, poorer outcomes in prostate cancer, and a higher risk of erectile dysfunction. The project culminated in creation of an educational poster intended for display in patient bathrooms in a medical setting.