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Full-Text Articles in Immune System Diseases
Counterregulatory Effects Of Ptx3 On Inflammation And Cellular Aging, Aaron L. Slusher
Counterregulatory Effects Of Ptx3 On Inflammation And Cellular Aging, Aaron L. Slusher
Theses and Dissertations
Pentraxin 3 (PTX3) is a vital regulator of innate immune function that has been shown to counterregulate pro-inflammatory signaling and protect against the development of cardiovascular disease (CVD). Less is known about how PTX3 may mitigate against CVD risk by regulating the pro-inflammatory response at the cellular level. Therefore, this dissertation details four manuscripts which aimed to examine the capacity of PTX3 to regulate the innate immune response of peripheral blood mononuclear cells (PBMCs) isolated from healthy adults. Manuscript 1 examined the capacity of PTX3 to alter the inflammatory milieu following in vitro stimulation of isolated PBMCs with the pro-inflammatory …