Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Immune System Diseases
Epigenetic Mechanisms Regulating The Functional Effects Of Chronic Alcohol Exposure Of Human Monocyte-Derived Dendritic Cells, Tiyash Parira
Epigenetic Mechanisms Regulating The Functional Effects Of Chronic Alcohol Exposure Of Human Monocyte-Derived Dendritic Cells, Tiyash Parira
FIU Electronic Theses and Dissertations
The effects of alcohol abuse are multi-dimensional since alcohol is widely known to affect both the innate and adaptive immune systems. Recently, epigenetics has come into focus and has been implicated in many diseases as well as substance abuse disorders. Therefore, research efforts of understanding the epigenetic mechanisms underlying substance abuse effects including alcohol abuse have become more predominant.
In our laboratory, we have studied different epigenetic changes induced by alcohol exposure including regulation of histone deacetylases (HDACs), histone quantity, and histone modifications such as acetylation and deacetylation. We have observed differential effects of acute and chronic alcohol exposure in …