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Full-Text Articles in Immune System Diseases
Restriction Of Hiv-1 Replication By Unique Trim22 Isoforms., Clayton Hattlmann
Restriction Of Hiv-1 Replication By Unique Trim22 Isoforms., Clayton Hattlmann
Electronic Thesis and Dissertation Repository
Understanding how the immune system reacts to HIV infection and why normal antiviral defenses are insufficient to fight infection is a key step towards creating better therapies. Several interferon-induced proteins, such as the tripartite motif protein TRIM22, are capable of restricting HIV-1 replication; however single nucleotide polymorphisms (SNPs) can dramatically impact the actions of these proteins. While the trim22 gene contains numerous SNPs, no study has addressed how these may affect TRIM22 functions. Here we provide the first direct comparison of two TRIM22 unique isoforms. Through confocal microscopy we observed these isoforms exhibit different patterns of localization. In vitro studies …