Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
Articles 1 - 2 of 2
Full-Text Articles in Immune System Diseases
Role Of Microrna-155 In Herpes Simplex Virus Pathogenesis, Siddheshvar Bhela
Role Of Microrna-155 In Herpes Simplex Virus Pathogenesis, Siddheshvar Bhela
Doctoral Dissertations
Ocular infection with herpes simplex virus 1 (HSV-1) can result in a chronic immunoinflammatory stromal keratitis (SK) lesion that is a significant cause of human blindness. These lesions are mainly orchestrated by IFN-gamma producing CD4+ T cells (Th1) and neutrophils. HSV being neurotropic in nature can also disseminate into the brain and lead to herpes simplex encephalitis (HSE). In this study we investigated the role of miR-155 in the pathogenesis of HSK and HSE.
The first part of the dissertation (I) reviews literature regarding the contribution of miRNAs in innate and adaptive immune responses. It also focuses on their involvement …
Modulating T Cell Responses To Control Stromal Keratitis, Tamara Antia Veiga Parga
Modulating T Cell Responses To Control Stromal Keratitis, Tamara Antia Veiga Parga
Doctoral Dissertations
Herpetic stromal keratitis (SK) is an immunoinflammatory corneal lesion caused by herpes simplex virus (HSV) infection. This infection, in some cases, can result in a chronic immunoinflammatory lesion that is the most common cause of infectious blindness in the developed world. Studies in animal models have revealed that SK lesions are orchestrated mainly by IFN-gamma producing CD4+ T cells (Th1) and neutrophils that infiltrate the corneal stroma.
The first part of this dissertation (I) reviews literature on HSV induced corneal SK immunopathology and the role of Tregs in viral infections. It also focuses on the understanding of HSV-1 induced immunoinflammatory …