Immune System Diseases Commons^™

Gut Integrity, Microbial Translocation, Immune Activation, Inflammation And Vitamin D In Drug Users Living With Hiv, Jacqueline S. Hernandez

FIU Electronic Theses and Dissertations

The purpose of this study was to examine associations between MT, immune activation, inflammation, gut integrity and vitamin D status in the context of cocaine use among People Living with HIV (PLWH). One hundred cocaine and non-cocaine users living with HIV were selected from the Miami Adult Studies in HIV cohort. Blood samples were collected to assess MT (LPS), immune activation (sCD163 and sCD27), inflammation (IL-6, TNF-a, hs-CRP, IL-17 and IL-22), gut integrity damage (I-FABP) and vitamin D status. Data on socio-demographic characteristics, anthropometrics, diet and disease progression were collected. Descriptive statistics, independent t-test, multiple linear and logistic regressions were …

Randomized Clinical Trial Of The Effect Of Oral Supplementation With N-Acetyl Cysteine And Glycine On Biomarkers Of Oxidative Stress And Inflammation In People Living With Hiv (Plwh) From The Mash Cohort, Alhanoof Al-Ohaly

FIU Electronic Theses and Dissertations

HIV infection has been associated with glutathione (GSH) depletion, oxidatively damaged DNA, and inflammation. People living with HIV (PLWH) have subnormal levels of GSH and elevated levels of inflammation biomarkers such as C-Reactive Protein (CRP). Failure of the antioxidant enzymatic system increases oxidatively damaged DNA. The objective of this double-blinded randomized clinical trial was to supplement PLWH with a combination of N-acetylcysteine, a powerful antioxidant, and glycine, a precursor of GSH or placebo for three months to decrease oxidative stress and inflammation.

The trial recruited 30 PLWH from the Miami Adult Studies on HIV (MASH) cohort at the FIU Research …