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Full-Text Articles in Immune System Diseases
Modulating T Cell Responses To Control Stromal Keratitis, Tamara Antia Veiga Parga
Modulating T Cell Responses To Control Stromal Keratitis, Tamara Antia Veiga Parga
Doctoral Dissertations
Herpetic stromal keratitis (SK) is an immunoinflammatory corneal lesion caused by herpes simplex virus (HSV) infection. This infection, in some cases, can result in a chronic immunoinflammatory lesion that is the most common cause of infectious blindness in the developed world. Studies in animal models have revealed that SK lesions are orchestrated mainly by IFN-gamma producing CD4+ T cells (Th1) and neutrophils that infiltrate the corneal stroma.
The first part of this dissertation (I) reviews literature on HSV induced corneal SK immunopathology and the role of Tregs in viral infections. It also focuses on the understanding of HSV-1 induced immunoinflammatory …