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Full-Text Articles in Endocrine System Diseases

Stroke In Brazil: A Neglected Disease, Paulo A. Lotufo Jan 2005

Stroke In Brazil: A Neglected Disease, Paulo A. Lotufo

Paulo A Lotufo

The turning point in the transition from infectious diseases to non-transmittable diseases in Brazil occurred in the 1960s, taking the country as a whole. However, considering the main cities, such as São Paulo and Rio de Janeiro, cerebrovascular disease mortality rates have surpassed the “old cardiovascular diseases” like rheumatic heart disease and syphilitic aortic disease since the end of World War II. Until the end of the 1980s, the burden of stroke mortality observed in the main Brazilian cities was higher than in the United States, Canada and western European countries, and similar to what is observed in Eastern Europe …


Why Brazil Does Not Have An Epidemic Of Chronic Diseases: Some Answers From Cardiovascular Diseases, Paulo A. Lotufo Jan 2005

Why Brazil Does Not Have An Epidemic Of Chronic Diseases: Some Answers From Cardiovascular Diseases, Paulo A. Lotufo

Paulo A Lotufo

No abstract provided.


The "Common Soil" Theory: Coronary Disease, Diabetes And Inflammation., Paulo A. Lotufo Jan 2005

The "Common Soil" Theory: Coronary Disease, Diabetes And Inflammation., Paulo A. Lotufo

Paulo A Lotufo

No abstract provided.


Progress Testing: Evaluation Of Four Years Of Application In The School Of Medicine, University Of São Paulo, Paulo A. Lotufo Jan 2005

Progress Testing: Evaluation Of Four Years Of Application In The School Of Medicine, University Of São Paulo, Paulo A. Lotufo

Paulo A Lotufo

Progress testing is a longitudinal tool for evaluating knowledge gains during the medical school years. Objectives: (1) To implement progress testing as a form of routine evaluation; (2) to verify whether cognitive gain is a continuous variable or not; and (3) to evaluate whether there is loss of knowledge relating to basic sciences in the final years of medical school. Methods: A progress test was applied twice a year to all students from 2001 to 2004. The mean percentage score was calculated for each school year, employing ANOVA with post hoc Bonferroni test evaluation for each test. Results:Progress testing was …


Castration Inhibits The Exercise-Induced Accumulation Of Hsp70 In Male Rodent Cardiac Muscle Tissue, Kevin Milne, David Thorp, C.W. Melling, Earl Noble Dec 2004

Castration Inhibits The Exercise-Induced Accumulation Of Hsp70 In Male Rodent Cardiac Muscle Tissue, Kevin Milne, David Thorp, C.W. Melling, Earl Noble

Jamie Melling

Intense exercise leads to accumulation of the inducible member of the 70-kDa family of heat shock proteins, Hsp70, in male, but not female, hearts. Estrogen is at least partially responsible for this difference. Because androgen receptors are expressed in the heart and castration leads to decreases in calcium regulatory proteins and altered cardiac function, testosterone (T) or its metabolites could also be involved. We hypothesized that removal of endogenous T production through castration would reduce cardiac Hsp70 accumulation after an acute exercise bout, whereas castrated animals supplemented with 5α-dihydrotestosterone (DHT) would show the intact male response. Fifty-four 8-wk-old male Sprague-Dawley …


A Wintertime Study Of Pahs In Fine And Coarse Aerosols In Sa˜O Paulo City, Brazil, Paulo A. Lotufo Dec 2004

A Wintertime Study Of Pahs In Fine And Coarse Aerosols In Sa˜O Paulo City, Brazil, Paulo A. Lotufo

Paulo A Lotufo

The Polycyclic aromatic hydrocarbons PAHs (naphthalene, acenaphthylene, acenaphthene, phenanthrene, fluoranthene, pyrene, benzo(a)anthracene, chrysene, benzo(b)fluoranthene, benzo(k)fluoranthene, benzo(a)pyrene, indeno(1,2,3-cd)pyrene and benzo(ghi)perylene) concentrations in fine (PM2.5) and coarse (PM2.5–10) atmospheric particulate matter were measured at Sa˜o Paulo city, Brazil. The dominant PAHcompounds were indeno(1,2,3-cd)pyrene, benzo(ghi)perylene and benzo(b)fluoranthene for both the fractions. The calculated ratios of some specific PAHs were in close agreement with those attributed to direct emissions of car exhaust. The factor analysis for PM2.5 produced four factors: Factor 1 was attributed to diesel emissions, Factor 2 was attributed to stationary combustion source, Factor 3 was attributed to vehicular emissions and Factor …