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Reexamining Cytolethal Distending Toxin's Host Cell Entry And Trafficking: The First Steps Down A Long Road, George Huhn
Reexamining Cytolethal Distending Toxin's Host Cell Entry And Trafficking: The First Steps Down A Long Road, George Huhn
Electronic Theses and Dissertations, 2020-
Cytolethal distending toxin (CDT) is a virulence factor produced by many Gram-negative bacteria, including Haemophilus ducreyi, the causative agent of genital chancroid. CDT is a heterotrimeric toxin consisting of a cell-binding domain (CdtA + CdtC) and a catalytic domain (CdtB) that has DNase activity. After binding to the host plasma membrane, CDT undergoes endocytosis and travels through the endosomes en route to the endoplasmic reticulum (ER). Only CdtB and CdtC arrive in the Golgi before moving to the ER. Only then does CdtB move into the nucleus, causing DNA damage that induces cell-cycle arrest and apoptosis. The previous CDT trafficking …
Cholera Transmission Dynamic Model With Environmental Impacts Of Plankton Reservoirs, Sweety Sarker
Cholera Transmission Dynamic Model With Environmental Impacts Of Plankton Reservoirs, Sweety Sarker
Electronic Theses and Dissertations, 2020-
Cholera is an acute disease that is a global threat to the world and can kill people within a few hours if left untreated. In the last 200 years, seven pandemics occurred, and, in some countries, it remains endemic. The World Health Organization (WHO) declared a global initiative to prevent cholera by 2030. Cholera dynamics are contributed by several environmental factors such as salinity level of water, water temperature, presence of plankton especially zooplankton such as cladocerans, rotifers, copepods, etc. Vibrio cholerae (V. cholerae) bacterium is the main reason behind the cholera disease and the growth of V. cholerae depends …