Bacterial Infections and Mycoses Commons^™

Role Of Aim2 Inflammasome In Pulmonary Host Defense Against Staphylococcus Aureus-Induced Pneumonia, Bibek Dhakal

LSU Master's Theses

Bacterial pneumonia is the leading cause of death in children under the age of five, claiming the lives of two million children each year. Staphylococcus aureus is the extracellular Gram-positive bacteria that causes necrotizing pneumonia. Moreover, the spread of antibiotic-resistant and hypervirulent strains has made treatment more challenging. Absent in melanoma 2 (AIM2) is a dsDNA-sensing cytosolic innate immune receptor that activates inflammasomes and is crucial for host defense against intracellular bacteria and DNA viruses. However, its role in extracellular bacterial pathogen-induced pneumonia is unclear. Therefore, understanding how AIM2 initiates host responses during Staphylococcus aureus is crucial for the development …