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Full-Text Articles in Bacterial Infections and Mycoses
Loop-Mediated Isothermal Amplification Methods For Diagnosis Of Bacterial Meningitis, Mitsuko Seki, Paul E. Kilgore, Eun Jin Kim, Makoto Ohnishi, Satoshi Hayakawa, Dong Wook Kim
Loop-Mediated Isothermal Amplification Methods For Diagnosis Of Bacterial Meningitis, Mitsuko Seki, Paul E. Kilgore, Eun Jin Kim, Makoto Ohnishi, Satoshi Hayakawa, Dong Wook Kim
Department of Pharmacy Practice
The rapid, accurate, and efficient identification of an infectious disease is critical to ensure timely clinical treatment and prevention in public health settings. In 2015, meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis was responsible for 379,200 (range: 322,700–444,700) deaths. Clinical features alone cannot determine whether bacterial meningitis is present; an analysis of cerebrospinal fluid (CSF) is essential. Loop-mediated isothermal amplification (LAMP) is a nucleic acid amplification method offering an alternative to polymerase chain reaction (PCR). LAMP-based assays for detection of three leading bacteria in CSF for diagnosis of meningitis have been established. The typing assays …
Niger: Meningitis, Rodrigo Medeiros
Niger: Meningitis, Rodrigo Medeiros
Global Public Health
Niger is a semi-presidential republic located in western Africa. The majority of the population lives in the most extreme southern part of the country since 80% of Niger’s territory is occupied by the Sahara desert. The desert has been spreading in recent years forcing people to leave their subsistence farms. The majority of the population lives with less than 1 dollar per day. The first meningitis outbreak lasted from 2002 until 2012, but the 2015 outbreak was the one that caused more damage to the countries located in the meningitis belt of sub-Saharan Africa. The meningitis belt is the place …