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Human Platelet Lysate Permits Scale-Up Of Dental Pulp Stromal Cells For Clinical Applications, Govindasamy Vijayendran, Ronald Veronica Sainik, Abdullah Aimi Naim, Nathan Kavitha R. Ganesan, Aziz Zeti Adura Che Abdul, Abdullah Mariam, Zain Rosnah, Abu Kasim Noor Hayaty, Musa Sabri, Bhonde Ramesh R.

Sabri Musa

Background aims. Dental pulp stromal cells (DPSC) are considered to be a promising source of stem cells in the field of regenerative therapy. However, the usage of DPSC in transplantation requires large-scale expansion to cater for the need for clinical quantity without compromising current good manufacturing practice (cGMP). Existing protocols for cell culturing make use of fetal bovine serum (FBS) as a nutritional supplement. Unfortunately, FBS is an undesirable additive to cells because it carries the risk of transmitting viral and prion diseases. Therefore, the present study was undertaken to examine the efficacy of human platelet lysate (HPL) as a …