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Dental Public Health and Education Commons™
Open Access. Powered by Scholars. Published by Universities.®
Dental pulp stem cells; insulin-producing cells; diabetes mellitus; IN-VITRO; TRANSPLANTATION; VIVO; SELF-REPAIR; CULTURE-CONDITIONS; COMPOSITE RESIN; DENTAL PULP STEM CELL; FUNCTIONALLY GRADED DESIGN; MULTI LAYERED POST; FUNCTIONALLY GRADED DENTAL POST; SOFT SKILLS; CLINICAL PAIRING; DENTAL PULP STROMAL CELLS; LONG-TERM EXPANSION; ROLLING BALL; BALL MILL;
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Differentiation Of Dental Pulp Stem Cells Into Islet-Like Aggregates, Noor Hayaty Abu Kasim Abu Kasim N.H.
Differentiation Of Dental Pulp Stem Cells Into Islet-Like Aggregates, Noor Hayaty Abu Kasim Abu Kasim N.H.
Noor Hayaty Abu Kasim Abu Kasim N.H.
The post-natal dental pulp tissue contains a population of multipotent mesenchymal progenitor cells known as dental pulp stromal/stem cells (DPSCs), with high proliferative potential for self-renewal. In this investigation, we explored the potential of DPSCs to differentiate into pancreatic cell lineage resembling islet-like cell aggregates (ICAs). We isolated, propagated, and characterized DPSCs and demonstrated that these could be differentiated into adipogenic, chondrogenic, and osteogenic lineage upon exposure to an appropriate cocktail of differentiating agents. Using a three-step protocol reported previously by our group, we succeeded in obtaining ICAs from DPSCs. The identity of ICAs was confirmed as islets by dithiozone-positive …