Open Access. Powered by Scholars. Published by Universities.®
- Institution
- Keyword
Articles 1 - 4 of 4
Full-Text Articles in Dental Materials
Biodegradable Nano-Hybrid Polymer Composite Networks For Regulating Cellular Behavior, Charles Henley Sprague
Biodegradable Nano-Hybrid Polymer Composite Networks For Regulating Cellular Behavior, Charles Henley Sprague
Masters Theses
Photo-crosslinkable polymeric biomaterials have emerged in the field of biomedical research to promote tissue regeneration. For example, scaffolds that can be crosslinked and hardened in situ have been known to make suitable implant alternatives. Since injectable and photo-crosslinkable biomaterials offer the advantage of being minimally invasive, they have emerged to compete with autografts, a current highly invasive method to repair diseased tissue. A series of novel photo-crosslinkable, injectable, and biodegradable nano-hybrid polymers consisting of poly(ε-caprolactone fumarate) (PCLF) and polyhedral oligomeric silsesquioxane (POSS) has been synthesized in our laboratory via polycondensation. To engineer the material properties of the nano-hybrid networks, varied …
Bioerodible Calcium Sulfate Bone Grafting Substitutes With Tailored Drug Delivery Capabilities, Bryan R. Orellana
Bioerodible Calcium Sulfate Bone Grafting Substitutes With Tailored Drug Delivery Capabilities, Bryan R. Orellana
Theses and Dissertations--Biomedical Engineering
Bone regeneration or augmentation is often required prior to or concomitant with implant placement. With the limitations of many existing technologies, a biologically compatible synthetic bone grafting substitute that is osteogenic, bioerodible, and provides spacing-making functionality while acting as a drug delivery vehicle for bioactive molecules could provide an alternative to ‘gold standard’ techniques.
In the first part of this work, calcium sulfate (CS) space-making synthetic bone grafts with uniformly embedded poly(β-amino ester) (PBAE) biodegradable hydrogel particles was developed to allow controlled release of bioactive agents. The embedded gel particles’ influence on the physical and chemical characteristics of CS was …
Toxicity Of Root Canal Filling Materials On Hela Cells And Fibroblasts, Eldon P. Carman
Toxicity Of Root Canal Filling Materials On Hela Cells And Fibroblasts, Eldon P. Carman
Loma Linda University Electronic Theses, Dissertations & Projects
A study was undertaken to determine the concentration at which a sealer reaches a point of nontoxicity. An in vitro model utilizing HeLa cells and human fibroblasts was used to observe the effect of various concentrations of eight freshly mixed and eight set root canal sealers. Evaluation of toxicity was determined by cell survival which was measured by incorporation of 3H-thymidine into the nucleic acid components of each cell type used. Each dilution tested was allowed direct contact with the cells for 24 hours before toxicity evaluation. The results indicate that all sealers at concentrations presently used are cytotoxic …
An Evaluation Of The Cytotoxicity Of Root Canal Filling Materials On Tissue Culture Cells In Vitro: Grossman's Sealer, N2 Permanent, Rickert's Sealer, And Cavit, Donald D. Antrim
An Evaluation Of The Cytotoxicity Of Root Canal Filling Materials On Tissue Culture Cells In Vitro: Grossman's Sealer, N2 Permanent, Rickert's Sealer, And Cavit, Donald D. Antrim
Loma Linda University Electronic Theses, Dissertations & Projects
An in vitro study using radioactively-labeled tissue culture cells was conducted over a seven-month period on Grossman's sealer, Rickert's sealer, N2 Permanent, and Cavit to determine the lasting and relative tissue toxicity of these materials.
From this study it was observed that all materials possess lasting tissue toxicity. When relative toxicity is considered, Grossman's is the most toxic, followed by N2, Rickert's and Cavit in descending order of toxicity. Both Grossman's and N2 would be considered highly toxic, with Rickert's displaying moderate toxicity. Cavit would be considered mild to moderate in toxicity.
The use of radioactively-labeled …