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Full-Text Articles in Dental Materials
Toxicity Of Root Canal Filling Materials On Hela Cells And Fibroblasts, Eldon P. Carman
Toxicity Of Root Canal Filling Materials On Hela Cells And Fibroblasts, Eldon P. Carman
Loma Linda University Electronic Theses, Dissertations & Projects
A study was undertaken to determine the concentration at which a sealer reaches a point of nontoxicity. An in vitro model utilizing HeLa cells and human fibroblasts was used to observe the effect of various concentrations of eight freshly mixed and eight set root canal sealers. Evaluation of toxicity was determined by cell survival which was measured by incorporation of 3H-thymidine into the nucleic acid components of each cell type used. Each dilution tested was allowed direct contact with the cells for 24 hours before toxicity evaluation. The results indicate that all sealers at concentrations presently used are cytotoxic …
An Evaluation Of The Cytotoxicity Of Root Canal Filling Materials On Tissue Culture Cells In Vitro: Grossman's Sealer, N2 Permanent, Rickert's Sealer, And Cavit, Donald D. Antrim
An Evaluation Of The Cytotoxicity Of Root Canal Filling Materials On Tissue Culture Cells In Vitro: Grossman's Sealer, N2 Permanent, Rickert's Sealer, And Cavit, Donald D. Antrim
Loma Linda University Electronic Theses, Dissertations & Projects
An in vitro study using radioactively-labeled tissue culture cells was conducted over a seven-month period on Grossman's sealer, Rickert's sealer, N2 Permanent, and Cavit to determine the lasting and relative tissue toxicity of these materials.
From this study it was observed that all materials possess lasting tissue toxicity. When relative toxicity is considered, Grossman's is the most toxic, followed by N2, Rickert's and Cavit in descending order of toxicity. Both Grossman's and N2 would be considered highly toxic, with Rickert's displaying moderate toxicity. Cavit would be considered mild to moderate in toxicity.
The use of radioactively-labeled …