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- Oral cancer (8)
- Oral mucosal lesions (8)
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- Areca quid (7)
- Betel chewers mucosa (7)
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- Betel quid (7)
- Betel quid related lesions (7)
- Biobanking (7)
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- Early detection (7)
- Lichen planus (7)
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- Oral squamous cell carcinoma (7)
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- Tobacco quid (7)
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- Traumatic eosinophilic granuloma (7)
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- ALCOHOL-CONSUMPTION (1)
- Alcohol (1)
- BETA-CAROTENE (1)
- Buccal mucosa (1)
- CIGARETTE-SMOKING (1)
Articles 1 - 16 of 16
Full-Text Articles in Dentistry
Aldehyde Dehydrogenase 2 (Aldh2) And Glutathione S-Transferase M1 (Gstm1) Polymorphisms In Relation To Oral Cancer Risk Among Malaysians, Karen-Ng L. P., Ghani W. M. N., Vimmitra A., Yuen K. M., Tan H. S., Lim S. J., Abraham M. T., Rahman Z. A. A., Tay K. K., Mustafa W. M. W., Jalil N., Norlida A., Cheong S. C., Rosnah Binti Zain
Aldehyde Dehydrogenase 2 (Aldh2) And Glutathione S-Transferase M1 (Gstm1) Polymorphisms In Relation To Oral Cancer Risk Among Malaysians, Karen-Ng L. P., Ghani W. M. N., Vimmitra A., Yuen K. M., Tan H. S., Lim S. J., Abraham M. T., Rahman Z. A. A., Tay K. K., Mustafa W. M. W., Jalil N., Norlida A., Cheong S. C., Rosnah Binti Zain
Prof. Dr. Rosnah Binti Zain
Introduction: ALDH2 is an enzyme involved in major oxidative pathway of alcohol metabolism while GSTM1 is a drug-metabolizing enzyme of acetaldehyde. It has been reported that the mutant ALDH2 allele and the absence of GSTM1 contributes to increased oral cancer risk due to reduced acetaldehyde metabolism. This study aims to determine ALDH2 and GSTM1 polymorphisms and its association with oral cancer risk. Method: An unmatched case-control study was conducted using 163 oral cancer patients and 87 non-cancer subjects selected from the OCRCC database. ALDH2 and GSTM1 genotypes were determined using PCR-RFLP from peripheral blood. Multiple logistic regression was employed to …
Significant Association Of High-Risk Human Papillomavirus (Hpv) But Not Of P53 Polymorphisms With Oral Squamous Cell Carcinomas In Malaysia, Saini R., Tang T. H., Rosnah Binti Zain, Cheong S. C., Musa K. I., Saini D., Ismail A. R., Abraham M. T., Mustafa W. M. W., Santhanam J.
Significant Association Of High-Risk Human Papillomavirus (Hpv) But Not Of P53 Polymorphisms With Oral Squamous Cell Carcinomas In Malaysia, Saini R., Tang T. H., Rosnah Binti Zain, Cheong S. C., Musa K. I., Saini D., Ismail A. R., Abraham M. T., Mustafa W. M. W., Santhanam J.
Prof. Dr. Rosnah Binti Zain
Purpose: The purpose of this study was to evaluate the role of HPV and p53 polymorphisms in oral squamous cell carcinomas (OSCC) affecting Malaysian population. Methods: We analysed frozen samples from 105 OSCC as well as 105 oral specimens derived from healthy individuals. PCR assays targeting two regions of the virus were used. PCR amplification for the analysis of p53 codon 72 arginine/proline alleles was carried out in a separate reaction. Results: HPV DNA was detected in 51.4% OSCC samples, while 24.8% controls were found to be HPV positive. HPV was found to be significantly associated with OSCC (P < 0.001, …
Factors Affecting Commencement And Cessation Of Betel Quid Chewing Behaviour In Malaysian Adults., Ghani W. M. N., Razak I. A., Yang Y. H., Talib N. A., Ikeda N., Axell T., Gupta P. C., Handa Y., Abdullah N., Rosnah Binti Zain
Factors Affecting Commencement And Cessation Of Betel Quid Chewing Behaviour In Malaysian Adults., Ghani W. M. N., Razak I. A., Yang Y. H., Talib N. A., Ikeda N., Axell T., Gupta P. C., Handa Y., Abdullah N., Rosnah Binti Zain
Prof. Dr. Rosnah Binti Zain
Background. Betel quid chewing is a common habit widely practiced in Southern Asian populations. However, variations are seen in the content of a betel quid across the different countries. Factors associated with commencement and cessation of this habit has been numerously studied. Unfortunately, data on Malaysian population is non-existent. This study aims to determine the factors associated with the inception and also cessation of betel quid chewing behaviour among Malaysian adults. Method. This study is part of a nationwide survey on oral mucosal lesions carried out among 11,697 adults in all fourteen states in Malaysia. The questionnaire included sociodemographic information …
Comments On "Transcriptional Profiling Of Oral Squamous Cell Carcinoma Using Formalin-Fixed Paraffin-Embedded Samples" By Saleh Et Al., Oral Oncol 46 (2010) 379-386 Reply, Rosnah Binti Zain
Comments On "Transcriptional Profiling Of Oral Squamous Cell Carcinoma Using Formalin-Fixed Paraffin-Embedded Samples" By Saleh Et Al., Oral Oncol 46 (2010) 379-386 Reply, Rosnah Binti Zain
Prof. Dr. Rosnah Binti Zain
Dear Editor, We thank Rentoft and colleagues for commenting on our paper “Transcriptional profiling of oral squamous cell carcinoma using formalin-fixed paraffin-embedded samples”, and agreeing that formalin-fixed paraffin embedded (FFPE) tissue specimens can be used for gene expression studies using microarrays, to identify genes that are significantly involved in oral carcinogenesis. The similarities and high concordance between the study by Rentoft et al. [1] and ours [2] is comforting and clearly supports the use of FFPE tissues in such experiments. More importantly, these studies act as independent validation for one another and strongly suggests that genes that were found to …
Selected Transcriptome Profiles Of Oral Cancer Suggestive Of Field Cancerisation Using Second Generation Sequencing, Rosnah Binti Zain, Anwar A., Karen-Ng L. P., Cheong S. C., Zaini Z., Prepagaran N., Hercus R., Idris N. M., Saidin A., Chia J. Y., Merican A. F., Abraham M. T., Tay K. K., Mustaffa W. M. W., Norain A. T., Rahman Z. A. A., Jallaludin A.
Selected Transcriptome Profiles Of Oral Cancer Suggestive Of Field Cancerisation Using Second Generation Sequencing, Rosnah Binti Zain, Anwar A., Karen-Ng L. P., Cheong S. C., Zaini Z., Prepagaran N., Hercus R., Idris N. M., Saidin A., Chia J. Y., Merican A. F., Abraham M. T., Tay K. K., Mustaffa W. M. W., Norain A. T., Rahman Z. A. A., Jallaludin A.
Prof. Dr. Rosnah Binti Zain
Objectives: To characterize differential gene expression between oral cancerous tissues and the normal mucosal tissues of oral cancer patients and oral mucosal tissues of cancer free patients using second generation sequencing. Methods: Five fresh frozen oral cancer tissue samples from smoking patients, with 2 samples of proximal normal were included in this study. An additional 8 samples consisting of normal oral mucosal tissues from the alveolar mucosa of non-cancer patients who had their wisdom tooth removed where 4 were smokers and another 4 were non-smokers was also included. The tissues and socio-demographic information were obtained from the Malaysian Oral Cancer …
Inherent Differential Propensity Of Dental Pulp Stem Cells Derived From Human Deciduous And Permanent Teeth, Govindasamy V., Abdullah A. N., Ronald V. S., Musa S., Aziz Z. A. C. A., Rosnah Binti Zain, Totey S., Bhonde R. R., Kasim N. H. A.
Inherent Differential Propensity Of Dental Pulp Stem Cells Derived From Human Deciduous And Permanent Teeth, Govindasamy V., Abdullah A. N., Ronald V. S., Musa S., Aziz Z. A. C. A., Rosnah Binti Zain, Totey S., Bhonde R. R., Kasim N. H. A.
Prof. Dr. Rosnah Binti Zain
Introduction: Lately, several new stem cell sources and their effective isolation have been reported that claim to have potential for therapeutic applications. However, it is not yet clear which type of stem cell sources are most potent and best for targeted therapy. Lack of understanding of nature of these cells and their lineagespecific propensity might hinder their full potential. Therefore, understanding the gene expression profile that indicates their lineage-specific proclivity is fundamental to the development of successful cell-based therapies. Methods: We compared proliferation rate, gene expression profile, and lineage-specific propensity of stem cells derived from human deciduous (SCD) and permanent …
Determination Of The Global Gene Expression Profile Of Oral Cancers Using Paraffin-Embedded Tissues, Saleh A., Rosnah Binti Zain, Hussaini H., Abraham M. T., Hamid S., Teo S. H., Cheong S. C.
Determination Of The Global Gene Expression Profile Of Oral Cancers Using Paraffin-Embedded Tissues, Saleh A., Rosnah Binti Zain, Hussaini H., Abraham M. T., Hamid S., Teo S. H., Cheong S. C.
Prof. Dr. Rosnah Binti Zain
Introduction: Oral cancer is a common disease in Asia. However, our ability to deliver effective and targeted therapy remains limited by our lack of understanding of the molecular pathogenesis of oral carcinogenesis. One method to understand the nature of genes and gene products whose aberrant expression promote malignant transformation is by using microarrays. However, such studies have been limited by the availability of specimens with intact RNA and adequate clinical data to enable the identification and validation biomarkers either as predictive or therapeutic tools. Objective: We have determined the global gene expression profiles of oral squamous cell carcinoma (OSCC) of …
Proliferative And Apoptotic Activity At The Tumour Invasive Front In Oral Squamous Cell Carcinoma, Ngeow W. C., Rosnah Binti Zain, Abidin Z., Phaik K. S., Kumar S.
Proliferative And Apoptotic Activity At The Tumour Invasive Front In Oral Squamous Cell Carcinoma, Ngeow W. C., Rosnah Binti Zain, Abidin Z., Phaik K. S., Kumar S.
Prof. Dr. Rosnah Binti Zain
Introduction: the tumour invasive front of squamous cell carcinoma (OSCC) has long been recognized as an important area which harbour prognostic information. The aim of the present study was to describe the expression of K1-67, MDM2 and Bcl-2 at the tumour invasive front in the buccal mucosa and also to investigate whether there is any association between the expression of K1-67, MDM2 and Bcl-2 with the certain sociodemographic characteristics, clinical and histopathological parameters. Materials and Methods: The sample of this study consisted of 31 biopsy cases of OSCC from the buccal mucosa. Immunohistochemistry was used with specific antibodies to K1-67, …
Aggressive, Multifocal Oral Verrucous Leukoplakia: Proliferative Verrucous Leukoplakia Or Not?, Ghazali N., Bakri M. M., Rosnah Binti Zain
Aggressive, Multifocal Oral Verrucous Leukoplakia: Proliferative Verrucous Leukoplakia Or Not?, Ghazali N., Bakri M. M., Rosnah Binti Zain
Prof. Dr. Rosnah Binti Zain
Background: Some oral verrucal lesions may constitute parts of the clinicopathological spectrum of proliferative verrucous leukoplakia (PVL). Because of its idiopathic yet sinister nature, it is possible that PVL may exist in other populations. The aim of this study was to review the clinicopathological features of persistent, multifocal, oral verrucal lesions in Malaysian population. Methods: Patients with multifocal oral verrucal lesions were selected from surgical and histopathological records. Results: Nine patients of diverse ethnicity with 43 biopsies were reviewed. The mean age at the presentation was 62 years. The most frequent sites affected were gum, sulci, cheek and tongue. Indulgence …
Cultural And Dietary Risk Factors Of Oral Cancer And Precancer - A Brief Overview, Rosnah Binti Zain
Cultural And Dietary Risk Factors Of Oral Cancer And Precancer - A Brief Overview, Rosnah Binti Zain
Prof. Dr. Rosnah Binti Zain
This is an update on cultural and dietary risk factors for oral precancer and cancer. It is an overview on ethnic differences (where possible) and socio-cultural risk factors (tobacco/areca nut/betel quid, alcohol use and dietary factors) in relation to oral precancer and cancer. While studies were from Western countries, India and China, this update also attempts to include and highlight some studies conducted in the Asia-Pacific region.
Tenascin-C In Betel-Quid Associated Lesions, Rosnah Binti Zain, Fukano H., Ikeda N., Kudeken W., Shrestha P., Ghazali M. N., Takai Y., Mori M.
Tenascin-C In Betel-Quid Associated Lesions, Rosnah Binti Zain, Fukano H., Ikeda N., Kudeken W., Shrestha P., Ghazali M. N., Takai Y., Mori M.
Prof. Dr. Rosnah Binti Zain
The expression of Tenascin-C, an adhesion modulating or anti- adhesive extracellular matrix protein, was evaluated in betel quid associated lesions of oral mucosa showing focal hyperkeratosis (n=15), dysplasia (n=15), oral submucous fibrosis (n=7) and oral squamous cell carcinoma (n=8). All the patients were chewers of betel quid containing betel leaves, areca nuts, lime and tobacco. The results obtained from this study were compared to similar lesions in smokers and non-quid users cited in the literature (Shrestha et al, Oral Oncol, 1994). An enhanced expression of TN-C was observed in epithelial connective tissue interface of quid associated hyperkeratotic and dyplastic mucosa. …
Pcna Expression In Epithelial Linings Of Odontogenic Cysts And Unicystic Ameloblastoma, Sudiono J., Rosnah Binti Zain
Pcna Expression In Epithelial Linings Of Odontogenic Cysts And Unicystic Ameloblastoma, Sudiono J., Rosnah Binti Zain
Prof. Dr. Rosnah Binti Zain
Proliferating cell nuclear antigen (PCNA) is a nuclear protein synthesized in the late G1 and S phase of the cell cycle. It is a useful marker for the proliferating fraction of cells in tissue specimens. The purpose of this study was to describe the expression of PCNA within epithelial linings of odontogenic cyst and to compare the proliferative activities of these lesion using PCNA labeling indices. A total of 61 cases of odontogenic cysts and unicystic ameloblastomas (18 radicular cysts, 16 dentigerous cysts, 15 odontogenic keratocysts (OKC) an 12 unicystic ameloblastomas) was studied. It was found that PCNA staining were …
Oral Mucosal Lesions Associated With Betel Quid, Areca Nut And Tobacco Chewing Habits: Consensus From A Workshop Held In Kuala Lumpur, Malaysia, November 25-27, 1996, Rosnah Binti Zain, Ikeda N., Gupta P. C., Warnakulasuriya S., Van Wyk C. W., Shrestha P., Axéll T.
Oral Mucosal Lesions Associated With Betel Quid, Areca Nut And Tobacco Chewing Habits: Consensus From A Workshop Held In Kuala Lumpur, Malaysia, November 25-27, 1996, Rosnah Binti Zain, Ikeda N., Gupta P. C., Warnakulasuriya S., Van Wyk C. W., Shrestha P., Axéll T.
Prof. Dr. Rosnah Binti Zain
A variety of betel/areca nut/tobacco habits have been reviewed and categorized because of their possible causal association with oral cancer and various oral precancerous lesions and conditions, and on account of their widespread occurrence in different parts of the world. At a recent workshop in Kuala Lumpur it was recommended that 'quid' be defined as 'a substance, or mixture of substances, placed in the mouth or chewed and remaining in contact with the mucosa, usually containing one or both of the two basic ingredients, tobacco and/or areca nut, in raw or any manufactured or processed form.' Clear delineations on contents …
A National Epidemiological Survey Of Oral Mucosal Lesions In Malaysia, Rosnah Binti Zain, Ikeda N., Razak I. A., Axéll T., Majid Z. A., Gupta P. C., Yaacob M.
A National Epidemiological Survey Of Oral Mucosal Lesions In Malaysia, Rosnah Binti Zain, Ikeda N., Razak I. A., Axéll T., Majid Z. A., Gupta P. C., Yaacob M.
Prof. Dr. Rosnah Binti Zain
The prevalence of oral mucosal lesions in Malaysia was determined by examining a representative sample of 11707 subjects aged 25 years and above throughout the 14 states over a period of 5 months during 1993/1994. A two-stage stratified random sampling was undertaken. A predetermined number of enumeration blocks, the smallest population unit in the census publication, was selected from each state. With the selected enumeration block, a systematic sample of living quarters was chosen with a random start. The survey instrument included a questionnaire on sociodemographic characteristics and a clinical examination. The clinical examination was carried out by 16 specially …
Peripheral Fibroma/Fibrous Epulis With And Without Calcifications. A Clinical Evaluation Of 204 Cases In Singapore, Rosnah Binti Zain, Fei Y. J.
Peripheral Fibroma/Fibrous Epulis With And Without Calcifications. A Clinical Evaluation Of 204 Cases In Singapore, Rosnah Binti Zain, Fei Y. J.
Prof. Dr. Rosnah Binti Zain
Peripheral fibroma/fibrous epulis accounts for the great majority of localised gingival swellings as was substantiated by various reports in the literature. A study was undertaken to investigate the clinical features of a series of 204 localised fibrous gingival swellings received by the Histopathology Laboratory, Department of Oral Surgery, National University of Singapore. The female patients were more affected than the male patients and the lesions occurred predominantly among the Chinese. The lesions were mainly pedunculated and most commonly occurred in anterior maxilla. The recurrence rate was about 10.3%. In conclusion the results obtained in this study were overall in agreement …
Association Between Cigarette-Smoking And Prevalence Of Oral Mucosal Lesions Among Malaysian Army Personnel, Rosnah Binti Zain, Razak I. A.
Association Between Cigarette-Smoking And Prevalence Of Oral Mucosal Lesions Among Malaysian Army Personnel, Rosnah Binti Zain, Razak I. A.
Prof. Dr. Rosnah Binti Zain
The association between cigarette smoking and the prevalence of oral mucosal lesions was examined in 495 Malaysian army personnel. No associations between cigarette smoking and recurrent aphthous ulcerations, pre-leukoplakia and frictional keratosis could be obtained in this study. Positive associations were found between cigarette smoking and leukoedema as well as denture stomatitis. There was a negative association between cigarette smoking and the presence of coated tongue.