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Full-Text Articles in Speech Pathology and Audiology
Advanced Phenotyping Of Otosclerosis In An Ontario Population And Two Large Newfoundland Families, Matthew B. Lucas
Advanced Phenotyping Of Otosclerosis In An Ontario Population And Two Large Newfoundland Families, Matthew B. Lucas
Electronic Thesis and Dissertation Repository
Otosclerosis is a relatively common hearing loss disorder characterized by abnormal bone growth in the otic capsule leading to stapes fixation. In approximately half of cases, otosclerosis is inherited as an autosomal dominant trait. Typically, gene discovery efforts rely on surgical confirmation, audiometry and occasionally acoustic reflexes to identify affected cases of otosclerosis within families, requiring that the otosclerosis was at an advanced stage to be detected. This makes it difficult to identify individuals with early otosclerosis. The use of advanced phenotyping to identify cases of otosclerosis was tested in an Ontario otosclerotic population as well as in two large …
Identification Of The Smallest Perceivable Interaural Time Differences, Sinthiya Thavam
Identification Of The Smallest Perceivable Interaural Time Differences, Sinthiya Thavam
Electronic Thesis and Dissertation Repository
Several studies have reported human threshold interaural time differences (ITDs) near 10 μs; however, none of these studies aimed to find the stimulus and experimental method that yields the lowest threshold. The goal of the current study is to systematically determine the stimulus and the experimental paradigm that yields the smallest threshold ITD and to provide an accurate reference value. We systematically varied seven parameters: stimulus waveform, stimulus level, stimulus duration, adaptive versus constant stimulus procedure, number of reference intervals, inter-stimulus pause duration, and inclusion versus exclusion of onset and offset ITD. The condition yielding the lowest threshold ITD was …