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Effect Of Epha4 Signaling Mutations On Auditory Function, Michelle R. Gerringer

Dissertations, 2014-2019

Neural pathways underlie the ability of the auditory system to perceive sound. Organization of neural pathways into functional auditory circuitry is accomplished in part by Eph and ephrin signaling proteins. One of these signaling proteins, the EphA4 receptor tyrosine kinase protein, acts as an axon-guidance molecule to aid in target selection and to maintain tonotopicity in the auditory brainstem and midbrain. Genetic mutations of the EphA4 protein have been shown to affect structural auditory development, but there is limited research which shows the functional effects of these mutations. The goal of the present study was to determine the functional effects …