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Prepulse Inhibition Of The Acoustic Startle Reflex To Obtain A Psychometric Function In Mice, Robyn Browne
Prepulse Inhibition Of The Acoustic Startle Reflex To Obtain A Psychometric Function In Mice, Robyn Browne
Dissertations, 2014-2019
The acoustic startle reflex (ASR) is an automated motor response to an unexpected and intense auditory stimulus (Ouagazzal, Reiss, & Romand, 2006). When an audible ‘prepulse’ stimulus is presented before the intense, startle-evoking stimulus (SES); the startle reflex response is reduced and this is known as prepulse inhibition (PPI). The degree of ASR inhibition serves as a measure of the behavioral salience of the prepulse (Carlson & Willott, 1996). This study aimed to obtain a psychometric function from the amount of PPI of the ASR that resulted from varying intensity levels of a prepulse stimulus (PPS).
Twelve mice were used …