Speech and Hearing Science Commons^™

Structural And Functional Vocal Fold Epithelial Integrity Following Injury, Ciara Leydon, Mitsuyoshi Imaizumi, David T. Yang, Susan L. Thibeault, Marvin Fried

Communication Disorders Faculty Publications

Objectives/Hypothesis: An intact epithelium is an important part of vocal fold defense. Damage to the epithelium can compromise vocal fold homeostasis and protection of the host tissue from viral and bacterial invasion. Elucidating the effects of damage on epithelial architectural and barrier integrity provides insight into the role of epithelium in protecting vocal folds. Using an animal model, we evaluated the time course of structural and functional epithelial restoration following injury. Study Design: Prospective, controlled animal study. Methods: Forty rats underwent surgery to remove vocal fold mucosa unilaterally. Larynges were harvested at five time intervals between 3 to 90 days …