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Full-Text Articles in Speech and Hearing Science
Pre-Pulse Inhibition Assessment Of Sound Localization In Mice, Kathryn C. Brooks
Pre-Pulse Inhibition Assessment Of Sound Localization In Mice, Kathryn C. Brooks
Senior Honors Projects, 2010-2019
The purpose of my Honors Research Project was to assist Dr. Megan
Klingenberg in completing part of the research in her final dissertation project. Dr.
Klingenberg’s project was based off of a study done by Allen and Ison in 2010.
This study tested the auditory spatial acuity of mice using pre-pulse inhibition of
the startle reflex as the response for detecting the sound stimulus. The goal of
Dr. Klingenberg’s AuD project was “to explore the methodological, functional, and
genetic influences on sound localization using pre-pulse inhibition of the acoustic
startle response in mice”. Dr. Klingenberg’s project was broken into three …
Pre-Pulse Inhibition Assessment Of Sound Localization In Mice: Methodological, Functional, And Genetic Considerations, Megan Klingenberg
Pre-Pulse Inhibition Assessment Of Sound Localization In Mice: Methodological, Functional, And Genetic Considerations, Megan Klingenberg
Dissertations, 2014-2019
Sound localization is an important aspect of normal hearing. The Eph/ephin family of signaling proteins, studied here, is known to guide the formation of central auditory connections in early development, particularly topographic inputs from the lateral superior olive (LSO) to the inferior colliculus (IC). Processing in the LSO and its influences on the IC are known to be heavily involved in sound localization tasks. One way to study sound localization in mice is through pre-pulse inhibition (PPI). PPI is the phenomenon by which a weak prestimulus inhibits the response to a subsequent startle stimulus. In studying sound localization, the prestimulus …