Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Addiction (1)
- Adolescence (1)
- Anxiety Disorders (1)
- BDNF (1)
- Bisphenol A (1)
-
- CORM-3 (1)
- Carbon monoxide (1)
- Compartment syndrome (1)
- Depressive Disorders (1)
- Dopamine (1)
- Endocrine-Disrupting Chemical (1)
- Estrogen (1)
- Estrogen Receptor-β signaling pathway (1)
- Fasciotomy (1)
- Fetal Development (1)
- Fetal Exposure (1)
- GABA (1)
- Glucocorticoid Signaling Pathway (1)
- Glutamate (1)
- Inflammation (1)
- Lung Disease (1)
- Lung Maturation (1)
- NF-κB signaling pathway (1)
- Neurodevelopment (1)
- Nicotine (1)
- Nucleus Accumbens (1)
- Prefrontal Cortex (1)
- Reduced Lung Function (1)
- Sensitivity (1)
- Sex Differences (1)
Articles 1 - 3 of 3
Full-Text Articles in Other Chemicals and Drugs
Sex Differences In Mood And Anxiety-Related Outcomes In Response To Adolescent Nicotine Exposure, Tsun Hay Jason Ng
Sex Differences In Mood And Anxiety-Related Outcomes In Response To Adolescent Nicotine Exposure, Tsun Hay Jason Ng
Electronic Thesis and Dissertation Repository
Nicotine dependence is causally linked to increased risk of mood/anxiety disorders in later life. Females are reported to experience a higher prevalence of anxiety/depressive disorders and challenges in smoking cessation therapies, suggesting a potential sex-specific response to nicotine exposure and mood/anxiety disorder risk. However, pre-clinical evidence of sex-specific responses to adolescent nicotine exposure is unclear. Thus, to determine any sex differences in anxiety/depressive-related outcomes, adolescent male and female Sprague Dawley rats received nicotine (0.4 mg/kg; 3x daily) or saline injections for 10 consecutive days, followed by behavioural testing, in-vivo electrophysiology and Western Blot analyses. Our results revealed that adolescent nicotine …
Therapeutic Application Of Carbon Monoxide In Acute Limb Compartment Syndrome, Aurelia Bihari
Therapeutic Application Of Carbon Monoxide In Acute Limb Compartment Syndrome, Aurelia Bihari
Electronic Thesis and Dissertation Repository
Acute limb compartment syndrome (CS), a devastating complication of musculoskeletal trauma, develops in response to elevation of the pressure within a closed osseofascial compartment, producing muscle- and limb-threatening ischemia. Full decompression of all involved compartments by fasciotomy is the current gold-standard therapy, but it must be performed within a surgical window of 6-8 hours, before tissue damage becomes permanent.
Carbon monoxide (CO), a byproduct of heme metabolism, has been shown protective in ischemia. While inhalation of CO leads to elevation of carboxyhemoglobin (COHb), recent development of transitional metal carbonyls, CO-releasing molecules (CO-RMs), particularly the water-soluble CORM-3, delivers CO in a …
Effects Of Prenatal Exposure To Bisphenol A On Fetal Lung Development, Ayten Hijazi
Effects Of Prenatal Exposure To Bisphenol A On Fetal Lung Development, Ayten Hijazi
Electronic Thesis and Dissertation Repository
Prenatal exposure to bisphenol A (BPA), one of the most prevalent endocrine disrupting chemicals, is associated with lung dysfunction and diseases in later life. However, it is unknown if this association has a fetal origin. In this thesis, a series of in vivo and in vitro experiments were conducted to determine the effects of prenatal exposure to BPA on fetal lung development, and define the underlying molecular mechanisms. Environmentally relevant doses of BPA were administered to pregnant mice via diet from embryonic day (E) 7.5 to 18.5. Fetal lungs were analyzed at E18.5 for changes in structure and expression of …