Open Access. Powered by Scholars. Published by Universities.®
Nucleic Acids, Nucleotides, and Nucleosides Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (1)
- Anatomy (1)
- Animals (1)
- Disease Modeling (1)
- Endocrine System Diseases (1)
-
- Enzymes and Coenzymes (1)
- Investigative Techniques (1)
- Medical Anatomy (1)
- Medical Cell Biology (1)
- Medical Physiology (1)
- Medical Sciences (1)
- Musculoskeletal Diseases (1)
- Musculoskeletal System (1)
- Organisms (1)
- Physiological Processes (1)
- Skin and Connective Tissue Diseases (1)
- Surgical Procedures, Operative (1)
- Therapeutics (1)
- Tissues (1)
- Institution
- Publication Type
Articles 1 - 2 of 2
Full-Text Articles in Nucleic Acids, Nucleotides, and Nucleosides
Rna Isolation In Duchenne Muscular Dystrophy (Dmd) Mice Models, Salem Abu Al-Burak
Rna Isolation In Duchenne Muscular Dystrophy (Dmd) Mice Models, Salem Abu Al-Burak
Undergraduate Student Research Internships Conference
Fibrosis is a progressive and typically irreversible disease process characterized by the excessive deposition of collagen in organs and in tissues of the musculoskeletal (MSK) system1,2. This process, which causes loss of organ and tissue function, can be initiated by micro-traumas3, an excessive and/or prolonged immune response1, the activation and proliferation of fibrosis-inducing progenitor cells4, and a pro-fibrotic extra-cellular microenvironment5. In parallel with the events that initiate fibrosis, genetic or environmental influences may cause cells and tissues to become predisposed to fibrosis development prior to initiation. This suggests that these …
Impact Of Single Nucleotide Polymorphisms On Hpa Axis Functionality In Depression, Claire Kelly
Impact Of Single Nucleotide Polymorphisms On Hpa Axis Functionality In Depression, Claire Kelly
Honors Theses
The hypothalamic-pituitary-adrenal (HPA) axis plays a primary role in stress response through the regulated secretion of the glucocorticoid hormone cortisol. Diseases of cortisol dysregulation such as Cushing’s syndrome (hypercortisolemia) and Addison’s Disease (hypocortisolemia) are both associated with depression. Based on this we, and others, have hypothesized that mutations in the genes for the glucocorticoid receptor (GR), the closely related mineralocorticoid receptor (MR), and regulatory proteins associated with cortisol or GR function may contribute to depression in the absence of hyper- or hypo-cortisolemia. Our study investigated the genotypic frequency in the clinical population of several single nucleotide polymorphisms (SNPs) that affect …