Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Atomic, Molecular and Optical Physics (1)
- Biological and Chemical Physics (1)
- Biology (1)
- Cancer Biology (1)
- Cell and Developmental Biology (1)
-
- Chemistry (1)
- Diseases (1)
- Immunology and Infectious Disease (1)
- Immunopathology (1)
- Life Sciences (1)
- Medical Sciences (1)
- Medical Specialties (1)
- Medicinal-Pharmaceutical Chemistry (1)
- Neoplasms (1)
- Other Medical Sciences (1)
- Physical Sciences and Mathematics (1)
- Physics (1)
- Quantum Physics (1)
- Radiation Medicine (1)
- Keyword
-
- 15-lipoxygenase-1 (15-LOX-1) (1)
- Azoxymethane (AOM) (1)
- Colitis-associated colorectal cancer (CAC) (1)
- Colorectal cancer (CRC) (1)
- Dextran sodium sulfate (DSS) (1)
-
- Docosahexaenoic acid (DHA) (1)
- E/D-series resolvins (RvE/D) (1)
- Eicosapentaenoic acid (EPA) (1)
- Gold nanoparticles (1)
- Hyperthermia (1)
- Inflammatory bowel disease (IBD) (1)
- Liposomal delivery (1)
- Nuclear-targeting (1)
- Pancreatic cancer (1)
- Polyunsaturated fatty acid (PUFA) (1)
- Radiation (1)
- Radiosensitization (1)
Articles 1 - 2 of 2
Full-Text Articles in Lipids
Nuclear-Targeted Gold Nanoparticles Enhance The Effects Of Radiation Therapy With And Without Liposomal Delivery, Maureen Aliru
Nuclear-Targeted Gold Nanoparticles Enhance The Effects Of Radiation Therapy With And Without Liposomal Delivery, Maureen Aliru
Dissertations & Theses (Open Access)
Less that 10% of pancreatic cancer patients are eligible for curative resection, and clinical trials evaluating chemoradiation in locally advanced patients with unresectable disease have been largely disappointing. New and creative therapeutic approaches are needed to address the unment need for treatment options. The objective of this thesis is to advance radiosensitization of treatment-resistant densely desmoplastic pancreatic cancer using nanoparticles to surmount biological barriers to effective particle distribution for DNA-targeting.
Clinical translation of radiosensitizing nanoparticles has stalled owing to technical challenges. Current strategies to use AuNPs for radiosensitization require large quantities of gold, kilovoltage x-rays, immediate irradiation after intravenous administration, …
Impact Of Epa And Dha Supplementation And 15-Lox-1 Expression On Colitis And Colitis-Associated Colorectal Cancer, Jonathan Jaoude
Impact Of Epa And Dha Supplementation And 15-Lox-1 Expression On Colitis And Colitis-Associated Colorectal Cancer, Jonathan Jaoude
Dissertations & Theses (Open Access)
Inflammatory bowel disease (IBD) patients not only suffer from colitis but also from increased morbidity and mortality of colitis-associated colorectal cancer (CAC). The enzyme 15-lipoxygenase-1 (15-LOX-1) is crucial to converting omega-3 fatty acid derivatives eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) to resolvins, potent anti-inflammatory products. 15-LOX-1 effects on the conversion of EPA and DHA to resolvins that subsequently exert anti-inflammatory and anti-tumorigenic effects have received little attention. To address this knowledge gap, we hypothesize that 15-LOX-1 expression in colonic epithelial cells is essential for resolvin biosynthesis from EPA and DHA to modulate immunophenotype, limit inflammation, promote resolution, and help …