Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- 15-lipoxygenase-1 (15-LOX-1) (1)
- 2-hydroxypropyl-β-cyclodextrin (1)
- Atherosclerosis (1)
- Atherosclerotic treatment (1)
- Azoxymethane (AOM) (1)
-
- Bacteroides vulgatus (1)
- Cholesterol (1)
- Clostridium bolteae (1)
- Colitis-associated colorectal cancer (CAC) (1)
- Colorectal cancer (CRC) (1)
- Cyclodextrin (1)
- Dextran sodium sulfate (DSS) (1)
- Docosahexaenoic acid (DHA) (1)
- E/D-series resolvins (RvE/D) (1)
- Eicosapentaenoic acid (EPA) (1)
- Growth inhibition (1)
- Gut bacteria (1)
- Gut microbiome (1)
- Inflammatory bowel disease (IBD) (1)
- Polyunsaturated fatty acid (PUFA) (1)
- Statin (1)
- Α-cyclodextrin (1)
Articles 1 - 2 of 2
Full-Text Articles in Lipids
Finding The Balance The Effects Of Α-Cyclodextrin, 2-Hydroxypropyl-Β-Cyclodextrin, And Cholesterol Bacteroides Vulgatus And Clostridium Bolteae, Bethany Weaver
Pence-Boyce STEM Student Scholarship
Atherosclerosis is a cardiovascular disease that is characterized by the hardening of arteries through the formation of cholesterol plaques. Cyclodextrins could potentially treat atherosclerosis by shrinking plaques. These cyclic oligosaccharides can make complexes with cholesterol but have also shown toxic side effects. This study looked for potential negative effects of cyclodextrins and cholesterol on gut bacteria. It was hypothesized that Bacteroides vulgatus will have decreased growth when grown in broth with cholesterol. In contrast, Clostridium bolteae will have decreased growth when grown in broth with cyclodextrins. Due to the fact that these bacteria are anaerobic, Clostridium bolteae and Bacteroides vulgatus …
Impact Of Epa And Dha Supplementation And 15-Lox-1 Expression On Colitis And Colitis-Associated Colorectal Cancer, Jonathan Jaoude
Impact Of Epa And Dha Supplementation And 15-Lox-1 Expression On Colitis And Colitis-Associated Colorectal Cancer, Jonathan Jaoude
Dissertations & Theses (Open Access)
Inflammatory bowel disease (IBD) patients not only suffer from colitis but also from increased morbidity and mortality of colitis-associated colorectal cancer (CAC). The enzyme 15-lipoxygenase-1 (15-LOX-1) is crucial to converting omega-3 fatty acid derivatives eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) to resolvins, potent anti-inflammatory products. 15-LOX-1 effects on the conversion of EPA and DHA to resolvins that subsequently exert anti-inflammatory and anti-tumorigenic effects have received little attention. To address this knowledge gap, we hypothesize that 15-LOX-1 expression in colonic epithelial cells is essential for resolvin biosynthesis from EPA and DHA to modulate immunophenotype, limit inflammation, promote resolution, and help …