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Gama-Lactams And The Reformatsky Reaction: New Tricks For Old Chemistry, Dylan Dupont
Gama-Lactams And The Reformatsky Reaction: New Tricks For Old Chemistry, Dylan Dupont
Honors Theses
DUPONT, DYLAN. An Alternative Synthetic Pathway to γ-Lactam Compounds
Through the Application of Novel Reformatsky-Type Chemistry. Department
of Chemistry, June 2020
ADVISOR: James C. Adrian Jr. Ph.D.
It is the intent of the present report to relate the results of our attempt to elucidate and optimize a novel preparation of γ-lactam compounds. To achieve this end, it is proposed that the use of novel Reformatsky-type chemistry may provide a viable means. Generally, it has herein been validated that employment of α-amino ketones in traditional Reformatsky chemistry will form the traditional Reformatsky ester-adduct, and that this adduct is capable of spontaneously …
Synthesis Of Fluorinated Pyrazoles Via Intra- And Intermolecular Cyclization Reactions, Matthew Saucier
Synthesis Of Fluorinated Pyrazoles Via Intra- And Intermolecular Cyclization Reactions, Matthew Saucier
Honors Theses
Pyrazole-based pharmaceuticals treat a wide array of diseases and conditions including obesity, diabetes, cancer, microbial and viral infections, pain and inflammation, and many neurological disorders. Syntheses for this biologically significant substrate have been well developed, but current methods to afford fluorinated pyrazoles are limited by variability and selectivity. By 2013, over 25% of all drugs available on the market contained the element fluorine due to its unique characteristics leading to improved target protein binding, bioavailability, and metabolic stability. In order to harness these pharmaceutical benefits of fluorine and overcome its difficulty in handling and stability, we set out to develop …