Amino Acids, Peptides, and Proteins Commons^™

The Development Of A Synthetic Route For A Disubsitituted Diphenylacetylene And Its Conformational Characteristics Upon Coordination To Tungsten: A Prospect For Beta-Sheet Studies, Francis Herman

Senior Theses and Projects

The study of β-sheet mimetics represents an important step in understanding the structural and function of β-sheets. The purpose of this report was to develop a β-sheet mimetic through a diphenylacetylene backbone, coordinate the complex to tungsten and determine the structural and conformational characteristics of the complex. In order to characterize the different compounds ESI-MS, ¹HNMR, COSY NMR, NOESY NMR, and ROESY NMR were employed. The diphenylacetylene backbone contained two phenyl substituents with a peptide chain of two amino acids. The β-sheet mimetic 1 was successfully synthesized utilizing peptide coupling reactions and a Sonogashira coupling reaction. Previous research by …