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Amino Acids, Peptides, and Proteins Commons™
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- Antiapoptitic proteins (1)
- Apoptosis Regulatory Proteins (1)
- Biomarkers (1)
- Bortezomib (1)
- Bortezomib Resistance (1)
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- Cardiac fibrosis markers (1)
- Drug Resistance (1)
- Galectin-3 (1)
- Heart Failure (1)
- Machine Learning (1)
- Mcl-1 (1)
- Multiple Myeloma (1)
- Myeloid Cell Leukemia Sequence 1 Protein (1)
- NT-proBNP (1)
- Preserved Ejection Fraction (1)
- Proteasome Inhibitors (1)
- Risk Assessment (1)
- TMAO (1)
- Trimethylamine N-oxide (1)
Articles 1 - 2 of 2
Full-Text Articles in Amino Acids, Peptides, and Proteins
Advancing Risk Stratification In Hfpef: Unveiling The Potential Of Cardiac Fibrosis Markers For Early Diagnosis And Enhanced Patient Outcomes, Mariam Abdeen
Rowan-Virtua Research Day
Heart failure with preserved ejection fraction (HFpEF) challenges clinicians due to its diverse presentation and limitations in traditional diagnostic criteria. This study delves into the potential of cardiac fibrosis markers like galectin-3, NT-proBNP, and trimethylamine N-oxide (TMAO) to enhance diagnostic precision and patient outcomes in HFpEF. A systematic review of sixteen relevant studies revealed that these biomarkers offer promise for early detection and improved risk assessment. For instance, TMAO indicates systemic implications of HFpEF, while galectin-3 shows predictive value across heart failure types. Additionally, machine-learning models incorporating multiple biomarkers predict significant risk of adverse outcomes. Despite these advances, challenges like …
Efficacy Of Mcl-1 Inhibitors In Multiple Myeloma Cells Resistant To Bortezomib, Emily Nelson, Omar S. Al-Odat, Sabrina M. Paparo, Daniel A. Guirguis, Gabriella Yao, Manoj Pandey, Subash Jonnalagadda, Tulin Budak-Alpdogan
Efficacy Of Mcl-1 Inhibitors In Multiple Myeloma Cells Resistant To Bortezomib, Emily Nelson, Omar S. Al-Odat, Sabrina M. Paparo, Daniel A. Guirguis, Gabriella Yao, Manoj Pandey, Subash Jonnalagadda, Tulin Budak-Alpdogan
Rowan-Virtua Research Day
Multiple myeloma (MM) is a type of cancer that affects plasma B cells. Patients with MM often experience frequent relapses and can develop resistance to drugs. As a medical researcher, it is important to understand the role of Mcl-1 in preventing intrinsic apoptosis and drug resistance. Mcl-1 belongs to the anti-apoptotic subgroup of Bcl-2 family proteins and plays a crucial role in these processes. Mcl-1 plays a crucial role in driving disease progression and contributing to drug resistance in MM. It has been observed that there is an increased expression of Mcl-1 in 52% of patients with MM during diagnosis, …